Self forming, thermodynamically stable liposomes and their applications

  • US 6,958,160 B1
  • Filed: 09/30/2002
  • Issued: 10/25/2005
  • Est. Priority Date: 12/20/2000
  • Status: Expired due to Term
First Claim
Patent Images

1. A liposome comprising:

  • one or more lipids where the total lipids have a Pa between about 0.84 and 0.88 and a Pv between about 0.88 and 0.93,where Pa is the packing parameter with respect to surface and Pv is the packing parameter with respect to volume,where one or more of the lipids is a diacylglycerol-PEG,where the melting point of the diacylglycerol-PEG is below about 40 degrees C., andwhere the acyl chains of the diacylglycerol-PEG are greater than or equal to 14 carbons in length.

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