Method and apparatus for monitoring respiratory gases during anesthesia

• US 6,981,947 B2
• Filed: 06/24/2002
• Issued: 01/03/2006
• Est. Priority Date: 01/22/2002
• Status: Expired due to Fees

• Current Assignee: University of Florida Research Foundation, Incorporated (State University System of Florida)
• Original Assignee: University of Florida Research Foundation, Incorporated (State University System of Florida)
• Inventors: Melker, Richard J.
• Primary Examiner(s): Hindenburg, Max F.
• Assistant Examiner(s): Natnithithadha, Navin
• Application Number:
  US10/178,877
• Publication Number:
  US 20030176804A1
• Time in Patent Office: 1,289 Days
• Field of Search: 600/532, 600/531, 600/529, 600/538, 600/533, 128/203.12, 128/203.13, 128/203.14, 128/203.15, 128/203.18, 128/203.22, 128/203.25, 128/204.18, 128/204.22, 128/204.23, 73/233
• US Class Current: 600/532
• CPC Class Codes: A61B 5/08 Detecting, measuring or recording devices for evaluating the respiratory organs A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/082 Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath A61B5/083, A61B5/091 take precedence
• CPC Class Codes: A61B 5/0836 Measuring rate of CO2 production
• CPC Class Codes: A61B 5/4821 Determining level or depth of anaesthesia A61B5/1106 takes precedence
• CPC Class Codes: A61B 5/7267 involving training the classification device
• CPC Class Codes: A61M 16/0051 with alarm devices
• CPC Class Codes: A61M 16/01 specially adapted for anaesthetising A61M16/104, A61M16/18 take precedence
• CPC Class Codes: A61M 16/026 specially adapted for predicting, e.g. for determining an information representative of a flow limitation during a ventilation cycle by using a root square technique or a regression analysis
• CPC Class Codes: A61M 2016/1035 the anaesthetic agent concentration
• CPC Class Codes: A61M 2230/437 the anaesthetic agent concentration
• CPC Class Codes: A61M 5/142 Pressure infusion, e.g. using pumps
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

A method and system is provided for monitoring delivery of anesthesia (inhalational and intravenous) and detecting the depth of anesthesia wherein at least one anesthetic agent is absorbed in patient'"'"'s bloodstream during the administration of anesthesia, which includes sampling inspired and expired gas; analyzing the gas for concentration of at least one substance indicative of the anesthetic agent using sensor technology such as free (unmetabolized) anesthetic agent or its metabolites; determining the effect of the agent based on that concentration; and determining depth of anesthesia based thereon.

Claims

1. A method of monitoring a patient during administration of anesthesia wherein said patient is connected to a breathing circuit, comprising:

exposing at least one sensor to inspired and expired gases; and

detecting one or more target substances with said sensor,

wherein at least one anesthetic agent is delivered intravenously, and wherein the one or more target substances are indicative of the at least one anesthetic agent.

2. The method of claim 1 wherein said target substance is an anesthetic agent.

3. The method of claim 1 wherein said target substance is a physiologic gas.

4. The method of claim 1 wherein said target substance is a gas supplied to a breathing circuit.

5. The method of claim 1 further comprising:

determining the depth of anesthesia based on the concentration of at least one target substance detected in said expired gases.

6. The method of claim 5 further comprising

controlling an infusion pump for delivering said at least one agent intravenously based on the depth of anesthesia determined.

7. The method of claim 5 wherein the concentration is measured to determine anesthetic blood concentration.

8. The method of claim 5 wherein the concentration is measured to determine analgesic blood concentration.

9. The method of claim 1 wherein separate sensors are exposed to inspired and expired gases.

10. The method of claim 1 wherein one or more target substances are detected after a predetermined period of time.

11. The method of claim 1 further comprising the step of using at least one flow sensor to detect flow of gases.

12. The method of claim 1 wherein the detecting step comprises detecting both presence and concentration of the target substance.

13. The method of claim 12 wherein the concentration is indicative of a rate of metabolism of the target substance.

14. The method of claim 1 wherein the steps are repeated periodically to monitor trending over time.

15. The method of claim 1 wherein the agent is for sedation.

16. The method of claim 1 wherein a combination of agents is administered.

17. The method of claim 1 wherein the detecting is continuous.

18. The method of claim 1 wherein the detecting is periodic.

19. The method of claim 1 further comprising the step of recording data from said sensor.

20. The method of claim 1 further comprising the step of transmitting data from said sensor.

21. The method of claim 1 further comprising comparing the substance detected with a predetermined signature profile.

22. The method of claim 1 further comprising

capturing a sample of expired gases prior to exposing said sensor to expired gases.

23. The method of claim 1 further comprising

dehumidifying expired gases prior to exposing said sensor to expired gases.

24. The method of claim 1 further comprising

detecting exhalation of the patient'"'"'s breath with a sensor.

25. The method of claim 1 wherein said target substance is an unbound anesthetic agent indicative of the anesthetic agent.

26. A method of monitoring a patient during administration of anesthesia wherein said patient is connected to a breathing circuit, comprising:

exposing at least one sensor to inspired and expired gases; and

detecting one or more target substances with said sensor,

wherein at least one anesthetic agent is administered through said breathing circuit, and wherein at least one additional anesthetic agent is delivered intravenously.

27. A method of monitoring a patient during intravenous administration of anesthesia wherein said patient is connected to a breathing circuit, comprising:

exposing at least one sensor to inspired and expired gases;

detecting one or more target substances with said sensor; and

determining the depth of amnesia based on the concentration of at least one target substance detected in said expired gases, wherein the target substance is for amnesia.

28. A method of monitoring a patient during intravenous administration of anesthesia wherein said patient is connected to a breathing circuit, comprising:

exposing at least one sensor to inspired and expired gases;

detecting one or more target substances with said sensor; and

determining the depth of analgesia based on the concentration of at least one target substance detected in said expired gases, wherein the target substance is for analgesia.

29. A method of monitoring a patient during intravenous administration of anesthesia wherein said patient is connected to a breathing circuit, comprising:

exposing at least one sensor to inspired and expired gases;

detecting one or more target substances with said sensor; and

determining the depth of muscle relaxation based on the concentration of at least one target substance detected in said expired gases, wherein the target substance is for muscle relaxation.

30. A method of monitoring a patient during administration of anesthesia wherein said patient is connected to a breathing circuit, comprising:

exposing at least one sensor to inspired and expired gases; and

detecting one or more target substances with said sensor,

wherein said target substance is an unbound anesthetic agent and a metabolite of an anesthetic agent indicative of the anesthetic agent.

31. A method of monitoring a patient during administration of anesthesia wherein said patient is connected to a breathing circuit, comprising:

exposing at least one sensor to inspired and expired gases;

detecting one or more target substances with said sensor; and

assigning a numerical value to the concentration as analyzed upon reaching a level of anesthetic effect in said patient and, thereafter, assigning higher or lower values to the concentration based on its relative changes,

wherein the detecting step comprises detecting both presence and concentration of the target substance, and wherein at least one anesthetic agent is delivered intravenously.

32. A method of monitoring a patient during administration of anesthesia wherein said patient is connected to a breathing circuit, comprising:

exposing at least one sensor to inspired and expired gases;

detecting one or more target substances with said sensor;

assigning a numerical value to the concentration as analyzed upon reaching a level of anesthetic effect in said patient and, thereafter, assigning higher or lower values to the concentration based on its relative changes; and

monitoring the concentration by monitoring changes in said value and adjusting administration of anesthesia to maintain a desired anesthetic effect,

wherein the detecting step comprises detecting both presence and concentration of the target substance, and wherein at least one anesthetic agent is delivered intravenously.

33. A method of monitoring a patient during administration of anesthesia wherein said patient is connected to a breathing circuit, comprising:

exposing a first sensor to inspired gases, wherein at least one inspired gas is an anesthetic agent;

exposing a second sensor to expired gases;

detecting one or more target substances with said first and second sensors; and

determining concentration of said target substances;

wherein the first and second sensors are different sensors.

34. A method of monitoring a patient during administration of anesthesia wherein said patient is connected to a breathing circuit, comprising:

exposing at least one sensor to inspired and expired gases; and

detecting one or more target substances with said sensor,

wherein at least one anesthetic agent is delivered intravenously and wherein said target substance is an anesthetic agent.

35. A method of monitoring a patient during administration of anesthesia wherein said patient is connected to a breathing circuit, comprising:

exposing at least one sensor to inspired and expired gases; and

detecting one or more target substances with said sensor,

wherein at least one anesthetic agent is delivered intravenously and wherein said target substance is a physiologic gas.

36. A method of monitoring a patient during administration of anesthesia wherein said patient is connected to a breathing circuit, comprising:

exposing at least one sensor to inspired and expired gases; and

detecting one or more target substances with said sensor,

wherein at least one anesthetic agent is delivered intravenously and wherein said target substance is a gas supplied to a breathing circuit.