Optimized formulation of tobramycin for aerosolization
DCFirst Claim
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1. An aerosol formulation consisting of 75 mg/ml of tobramycin dissolved in an aqueous solution containing 0.45% sodium chloride;
- wherein the pH is between 4.0 and 5.5 and the osmolarity ranges between 250 and 450 mOsm/l.
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Abstract
The invention provides a tobramycin formulation for delivery by aerosolization in the form of additive-free, isotonic solution whose pH has been optimised to ensure adequate shelf-life at room temperature. Said formulation can be advantageously used for the treatment and prophylaxis of acute and chronic endobronchial infections, in particular those caused by the bacterium Pseudomonas aeruginosa associated to lung diseases such as cystic fibrosis.
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13 Claims
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1. An aerosol formulation consisting of 75 mg/ml of tobramycin dissolved in an aqueous solution containing 0.45% sodium chloride;
wherein the pH is between 4.0 and 5.5 and the osmolarity ranges between 250 and 450 mOsm/l. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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