Methods to mobilize progenitor/stem cells

CAFC
  • US 6,987,102 B2
  • Filed: 07/30/2002
  • Issued: 01/17/2006
  • Est. Priority Date: 07/31/2001
  • Status: Active Grant
First Claim
Patent Images

1. A method to obtain progenitor and/or stem cells from a subjectwhich method comprises(a) administering to said subject a compound of the formula
Z-linker-Z′





  • (1)or pharmaceutically acceptable salt or prodrug form thereofwherein Z is a cyclic polyamine containing 9–

    32 ring members of which 2–

    8 are nitrogen atoms, said nitrogen atoms separated from each other by at least 2 carbon atoms, and wherein said heterocycle may optionally contain additional heteroatoms besides nitrogen and/or may be fused to an additional ring system;

    or Z is of the formula embedded imagewherein A comprises a monocyclic or bicyclic fused ring system containing at least one N and B is H or an organic moiety of 1–

    20 atoms,Z′

    is either embodied in a form as defined by Z above, or is of the formula


    N(R)—

    (CR2)n

    Xwherein each R is independently H or straight, branched or cyclic alkyl (1–

    6C), n is 1 or 2, and X is an aromatic ring, including heteroaromatic rings, or is a mercaptan;



    linker”

    represents a bond, alkylene (1–

    6C) or may comprise aryl, fused aryl, and/or oxygen atoms contained in an alkylene chain, and/or may contain keto groups and/or nitrogen or sulfur atoms;

    in an amount effective to mobilize said progenitor and/or stem cells into the peripheral blood of said subject;

    followed by(b) harvesting said progenitor and/or stem cells by apheresis.

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