Method for obtaining aqueous formulations of oxidation-sensitive active principles

  • US 6,992,218 B2
  • Filed: 06/06/2001
  • Issued: 01/31/2006
  • Est. Priority Date: 06/06/2000
  • Status: Expired due to Term
First Claim
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1. A method for preparing an aqueous solution with an active nature susceptible to oxidation, which is paracetamol, while preserving for a prolonged period, comprising deoxygenation of the solution by bubbling with at least one inert gas and/or placing under vacuum, until the oxygen content is below 2 ppm, and optionally the aforementioned aqueous solution with an active principle is topped with an inert gas atmosphere heavier than air and placed in a closed container in which the prevailing pressure is 65,000 Pa maximum, and the oxygen content of the aqueous solution is below 2 ppm, and optionally the deoxygenation of the solution is completed by addition of an antioxidant.

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