Method and apparatus using alternative site glucose determinations to calibrate and maintain noninvasive and implantable analyzers

  • US 6,998,247 B2
  • Filed: 02/28/2003
  • Issued: 02/14/2006
  • Est. Priority Date: 03/08/2002
  • Status: Expired due to Fees
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First Claim
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1. A method of controlling sample site disparity error in calibration of a noninvasive glucose analyzer comprising:

  • collecting one or more noninvasive signals from a subject'"'"'s body at an alternative sampling site, said alternative sampling site having a location that is among those sites that are selected when performing an alternative invasive glucose determination, said alternative sampling site being located at a region other than said subject'"'"'s fingertips or toes;

    invasively determining an alternative reference glucose measurement corresponding in time to each noninvasive signal from said body at an alternative reference measurement site, said alternative reference measurement site located at a region of the body having a tissue matrix substantially identical or equivalent to a tissue matrix at said alternative sampling site so that error due to a discrepancy between glucose concentration at said alternative sampling site and said alternative reference measurement site is reduced or eliminated, and;

    any of the steps of;

    calibrating said glucose analyzer utilizing a calibration model calculated from said one or more noninvasive signals and said alternative reference glucose measurements; and

    maintaining calibration of said glucose analyzer by utilizing said one or more noninvasive signals and said alternative reference glucose measurements to select, adjust and/or correct a calibration model.

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