Compositions for, and methods of, treating atherosclerosis

  • US 6,998,417 B2
  • Filed: 04/22/2002
  • Issued: 02/14/2006
  • Est. Priority Date: 04/02/1996
  • Status: Expired due to Term
First Claim
Patent Images

1. A method of therapeutic or prophylactic treatment of atherosclerosis, thrombosis, heart attack, stroke or vascular circulation problems comprising administering to a subject in need thereof an effective amount of a polymeric compound of the formula An or a pharmaceutically acceptable salt thereof:

  • embedded imagewhereinn is an integer from 2 to 18, such that there is at least one terminal monomeric unit A, and one or a plurality of additional monomeric units;

    R is 3-(α


    OH, 3-(β



    bonding between adjacent monomers takes place at positions selected from the group consisting of 4, 6 and 8;

    a bond of an additional monomeric unit in position 4 has alpha or beta stereochemistry;

    X, Y and Z are selected from the group consisting of monomeric unit A, hydrogen, and a sugar, with the provisos that as to the at least one terminal monomeric unit, bonding of the additional monomeric unit thereto is at position 4 and optionally y=Z=hydrogen;

    wherein the subject is a human or a veterinary animal.

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