Method and apparatus for reducing coupling between signals

• US 7,003,338 B2
• Filed: 07/08/2003
• Issued: 02/21/2006
• Est. Priority Date: 07/08/2003
• Status: Active Grant

• Current Assignee: Cercacor Laboratories
• Original Assignee: Masimo Corporation
• Inventors: Weber, Walter M., Al-Ali, Ammar
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US10/615,333
• Publication Number:
  US 20050010092A1
• Time in Patent Office: 959 Days
• Field of Search: 600322-323, 600/336
• US Class Current: 600/336
• CPC Class Codes: A61B 2562/0238 Optical sensor arrangements for performing transmission measurements on body tissue
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: A61B 5/7214 using signal cancellation, e.g. based on input of two identical physiological sensors spaced apart, or based on two signals derived from the same sensor, for different optical wavelengths
• CPC Class Codes: A61B 5/7221 Determining signal validity, reliability or quality A61B5/7207 and A61B5/7217 take precedence
• CPC Class Codes: A61B 5/7228 Signal modulation applied to the input signal sent to patient or subject; demodulation to recover the physiological signal modulation H03C

Abstract

A method and an apparatus for separating a composite signal into a plurality of signals is described. A signal processor receives a composite signal and separates a composite signal in to separate output signals. Feedback from one or more of the output signals is provided to a configuration module that configures the signal processor to improve a quality of the output signals. In one embodiment, the signal processor separates the composite signal by applying a first demodulation signal to the composite signal to generate a first output signal. In one embodiment, the signal processor also applies a second demodulation signal to the composite signal to generate a second output signal. In one embodiment, a phase and/or amplitude of the first demodulation signal and a phase and/or amplitude of the second demodulation signal are selected to reduce crosstalk. In one embodiment, the composite signal is obtained from a detector in a system for measuring one or more blood constituents.

Claims

1. A method of reducing crosstalk between two signals generated by applying a first pulse and a second pulse to measure a parameter, wherein said first pulse and said second pulse are applied periodically at a first repetition rate defining a period, and wherein said first pulse is generated during a first interval in each period and said second pulse is generated during a second interval in each period, said first and second pulses producing first and second parametric signals responsive to said parameter, said first and second parametric signals being received by a detector which outputs a composite signal responsive to said first and second parametric signals, said method comprising:

applying a first demodulation signal to said composite signal to generate a first demodulated output signal, said first demodulation signal comprising at least one component having at least a first amplitude and a first phase;

applying a second demodulation signal to said composite signal to generate a second demodulated output signal, said second demodulation signal comprising at least one component having at least a second amplitude and a second phase;

lowpass filtering said first demodulated output signal to generate a first recovered output signal responsive to said first parametric signal;

lowpass filtering said second demodulated output signal to generate a second recovered output signal responsive to said second parametric signal; and

choosing at least one of said first phase, said second phase, said first amplitude, and said second amplitude to reduce crosstalk components in said first recovered output signal and said second recovered output signal based at least in part on data obtained from said detector during a calibration procedure, wherein said choosing comprises;

applying said first light pulse during a first time period and measuring said first recovered output during said first time period as a first calibration output and measuring said second recovered output during said first time period as a second calibration output;

applying said second light pulse during a second time period and measuring said first recovered output during said first time period as a third calibration output and measuring said second recovered output during said second time period as a fourth calibration output; and

computing said first demodulation signal from at least said first calibration output, said second calibration output, said third calibration output, and said fourth calibration output.

2. The method of claim 1, wherein at least a portion of said first demodulation signal is computed from a ratio of said first calibration pulse and said second calibration pulse.

3. A method of reducing crosstalk between two signals generated by applying a first pulse and a second pulse to measure a parameter, wherein said first pulse and said second pulse are applied periodically at a first repetition rate defining a period, and wherein said first pulse is generated during a first interval in each period and said second pulse is generated during a second interval in each period, said first and second pulses producing first and second parametric signals responsive to said parameter, said first and second parametric signals being received by a detector which outputs a composite signal responsive to said first and second parametric signals, said method comprising:

applying a first demodulation signal to said composite signal to generate a first demodulated output signal, said first demodulation signal comprising at least one component having at least a first amplitude and a first phase;

applying a second demodulation signal to said composite signal to generate a second demodulated output signal, said second demodulation signal comprising at least one component having at least a second amplitude and a second phase;

lowpass filtering said first demodulated output signal to generate a first recovered output signal responsive to said first parametric signal;

lowpass filtering said second demodulated output signal to generate a second recovered output signal responsive to said second parametric signal; and

choosing at least one of said first phase, said second phase, said first amplitude, and said second amplitude to reduce crosstalk components in said first recovered output signal and said second recovered output signal based at least in part on data obtained from said detector during a calibration procedure, wherein said first demodulation signal comprises a sum of a first demodulation component having a first amplitude and a second demodulation component having a second amplitude, said second demodulation component in quadrature with said first demodulation component and wherein choosing said first phase comprises choosing said first amplitude and said second amplitude.

4. A method of reducing crosstalk between two signals generated by applying a first pulse and a second pulse to measure a parameter, wherein said first pulse and said second pulse are applied periodically at a first repetition rate defining a period, and wherein said first pulse is generated during a first interval in each period and said second pulse is generated during a second interval in each period, said first and second pulses producing first and second parametric signals responsive to said parameter, said first and second parametric signals being received by a detector which outputs a composite signal responsive to said first and second parametric signals, said method comprising:

applying a first demodulation signal to said composite signal to generate a first demodulated output signal, said first demodulation signal comprising at least one component having at least a first amplitude and a first phase;

applying a second demodulation signal to said composite signal to generate a second demodulated output signal, said second demodulation signal comprising at least one component having at least a second amplitude and a second phase;

lowpass filtering said first demodulated output signal to generate a first recovered output signal responsive to said first parametric signal;

lowpass filtering said second demodulated output signal to generate a second recovered output signal responsive to said second parametric signal; and

choosing at least one of said first phase, said second phase, said first amplitude, and said second amplitude to reduce crosstalk components in said first recovered output signal and said second recovered output signal based at least in part on data obtained from said detector during a calibration procedure, wherein said first demodulation signal comprises a sum of a sinusoidal component having a first amplitude and a cosinusoidal component having a second amplitude, and wherein choosing said first phase comprises choosing said first amplitude and said second amplitude by using a least squares minimization of an error corresponding to said crosstalk.

5. The method of claim 4, wherein said error is integrated over a time period.

6. The method of claim 4, wherein said error is integrated over a time period corresponding to an integer number of cycles of said sinusoidal component.

7. A pulse oximetry system, comprising:

a modulation signal generator, said modulation signal generator generating a first modulation signal comprising a first pulse which repeats at a first repetition frequency, said first pulse having a duty cycle, said modulation signal generator generating a second modulation signal comprising a second pulse which also repeats at said first repetition frequency, said second pulse having a duty cycle, said second pulse occurring at non-overlapping times with respect to said first pulse, said first and second pulses comprising a plurality of components wherein a first component has a frequency corresponding to said repetition frequency and a second component has a second frequency corresponding to twice said first frequency, said second component having an amplitude which has a first predetermined relationship to an amplitude of said first component;

a first transmitter which emits electromagnetic energy at a first wavelength in response to said first pulse;

a second transmitter which emits electromagnetic energy at a second wavelength in response to said second pulse;

a detector which receives electromagnetic energy at said first and second wavelengths after passing through a portion of a subject and which generates a detector output signal responsive to the received electromagnetic energy, said detector output signal including a signal component responsive to attenuation of said electromagnetic energy at said first wavelength and a signal component responsive to attenuation of said electromagnetic energy at said second wavelength;

a first demodulator which multiplies said detector signal by a first demodulation signal and generates a first demodulated output signal;

a second demodulator which multiplies said detector signal by a second demodulation signal and generates a second demodulated output signal; and

a configuration module to configure said first demodulation signal and said second demodulation signal to substantially diagonalize said first demodulator and said second demodulator.

8. The pulse oximetry system of claim 7, wherein said configuration module selects a phase relationship between said first demodulation signal and said second demodulation signal.

9. The pulse oximetry system of claim 7, wherein said configuration module configures said first demodulation signal and said second demodulation signal using, at least in part, data obtained during a calibration period.

10. The pulse oximetry system of claim 7, wherein said configuration module configures said first demodulation signal and said second demodulation signal using, at least in part, calibration data obtained during a calibration period, said calibration data comprising first and second calibration data corresponding to said first and second demodulated output signals during a first time period and third and fourth calibration data corresponding to said first and second demodulated output signals during a second time period, said second transmitter turned off during said first time period, said first transmitter turned off during said second time period.

11. The pulse oximetry system of claim 7, wherein said configuration module configures said first demodulation signal and said second demodulation signal by adjusting initial parameters that define said first demodulation signal and said second demodulation signal, said configuration module adjusting said initial parameters using, at least in part, calibration data obtained during a calibration period, said calibration data comprising first and second calibration data corresponding to said first and second demodulated output signals during a first time period and third and fourth calibration data corresponding to said first and second demodulated output signals during a second time period, said second transmitter turned off during said first time period, said first transmitter turned off during said second time period.