Method and apparatus for monitoring cerebral physiology

• US 7,020,505 B1
• Filed: 01/07/1999
• Issued: 03/28/2006
• Est. Priority Date: 01/08/1998
• Status: Expired due to Fees

• Current Assignee: Curators of the University of Missouri (University of Missouri)
• Original Assignee: Curators of the University of Missouri (University of Missouri)
• Inventors: Huckfeldt, Roger Eugene, Phillips, Jeffrey Owen
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US09/600,012
• Time in Patent Office: 2,637 Days
• Field of Search: 600309-310, 600/361, 600/300, 600/378, 604 19- 21, 604 27- 28
• US Class Current: 600/310
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/14553 specially adapted for cerebral tissue
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/4064 Evaluating the brain A61B5/031, A61B5/369, A61B5/14553 take precedence

Abstract

A method and apparatus for predicting the outcome of head injury trauma by monitoring cerebrospinal fluid (CSF) characteristics, preferably my monitoring the pH of CSF. The apparatus includes a catheter with a wall section adapted to permit CSF to flow therein, and a sensor located within the catheter such that the CSF is permitted to flow adjacent the tip of the sensor.

Claims

1. A method of monitoring the cerebral cellular environment of a patient for prognosis and for providing information for treatment comprising:

providing an opening in the skull of said patient;

inserting a catheter through said opening into a region of cerebrospinal fluid (CSF) within said skull of said patient, said catheter having a flow section capable of permitting said CSF to flow therein;

positioning said flow section of said catheter into said region of CSF;

placing at least one sensor capable of sensing pH into said flow section within said catheter to enable said CSF to flow adjacent said sensor so that said sensor may sense at least one characteristic, including pH, of said CSF;

monitoring changes of said at least one characteristic of said CSF within the initial 48 hours following head trauma; and

predicting the outcome of the head trauma based on the monitored changes.

2. The method of claim 1, wherein said region of CSF is a cerebral ventricle.

3. The method of claim 1, further comprising:

fixing said catheter in place in said opening of said skull to prevent movement of said catheter relative to said opening in said skull.

4. The method of claim 1, wherein said inserting step further comprises:

inserting said catheter into said region of CSF until expression of said CSF indicates said catheter has reached said cerebral ventricle.

5. The method of claim 1, further comprising:

connecting said catheter to an extension tube; and

locking said sensor within said catheter.

6. The method of claim 5, further comprising:

draining said CSF through said catheter, wherein said monitored characteristic further includes intracranial pressure.

7. The method of claim 1, wherein said characteristic monitored further includes a characteristic selected from the group consisting of partial oxygen pressure, temperature, carbon dioxide concentration, and combinations thereof.

8. The method of claim 7, wherein the pH of said CSF is monitored and compared with a base line.

9. The method of claim 1, further comprising:

monitoring said characteristic on a continuous basis;

collecting data regarding said characteristic;

storing said data; and

comparing said data.

10. The method of claim 1, wherein said monitoring step comprises:

monitoring said characteristic within the initial 24 hours following trauma.

11. A method of monitoring at least one characteristic of cerebrospinal fluid (CSF) of a patient for prognosis and for providing information for treatment comprising:

providing an opening in the skull of said patient through which a region of CSF is accessible;

inserting a catheter through said opening into said region of CSF in said patient, said catheter having a flow section capable of permitting said CSF to flow therein;

positioning said flow section of said catheter into said region of CSF;

placing at least one sensor capable of sensing pH into said flow section within said catheter to enable said CSF to flow adjacent said sensor so that said sensor may sense at least one characteristic, including pH, of said CSF;

monitoring changes of said at least one characteristic of said CSF within the initial 48 hours following head trauma; and

predicting the outcome of the head trauma based on the monitored changes.

12. The method of claim 11, further comprising;

fixing said catheter in place in said opening of said patient to prevent movement of said catheter relative to said opening in said patient.

13. The method of claim 11, wherein said inserting step further comprises:

inserting said catheter into said region of CSF until expression of said CSF indicates said catheter has reached said region of CSF.

14. The method of claim 11, further comprising:

connecting said catheter to an extension tube; and

locking said sensor within said catheter.

15. The method of claim 14, further comprising:

draining said CSF through said catheter.

16. The method of claim 11, wherein said characteristic monitored further includes a characteristic selected from the group consisting of partial oxygen pressures temperature, carbon dioxide concentration, and combinations thereof.

17. The method of claim 16, wherein the pH of said CSF is monitored and compared with a base line.

18. The method of claim 11, further comprising:

monitoring said characteristic on a continuous basis;

collecting data regarding said characteristic;

storing said data; and

comparing said data.

19. The method of claim 11, wherein said monitoring step comprises:

monitoring said characteristic within the initial 24 hours following trauma.

20. An apparatus for monitoring the cerebral cellular environment of a patient, comprising:

a catheter having a wall section adapted to permit cerebrospinal fluid (CSF) to flow therein, said catheter adapted for introduction through an opening in a skull of a patient; and

at least one sensor capable of sensing pH located within a porous sheath, wherein said porous sheath is located within said catheter such that said CSF is permitted to flow through said porous sheath and adjacent said sensor;

said sensor further being capable of monitoring at least one characteristic, including pH, of said CSF over time.

21. The apparatus of claim 20, wherein said catheter is a dual lumen catheter comprising a first lumen and a second lumen.

22. The apparatus of claim 21, wherein said sensor is housed in said first lumen and said CSF is drawn through said second lumen.

23. The apparatus of claim 20, wherein said characteristic monitored further includes a characteristic selected from the group consisting of partial oxygen pressure, temperature, carbon dioxide concentration, and combinations thereof.

24. The apparatus of claim 20, further comprising:

equipment for monitoring, storing, and, comparing data of said characteristic from said sensor over time.

25. An apparatus for monitoring at least one characteristic of cerebrospinal fluid (CSF) of a patient, comprising:

a catheter having a wall section adapted to permit said CSF to flow therein, said catheter adapted for introduction through an opening in said patient through which a region of CSF is accessible; and

at least one sensor capable of sensing pH located within a porous sheath, wherein said porous sheath is located within said catheter such that said CSF is permitted to flow through said porous sheath and adjacent said sensor;

said sensor further being capable of monitoring at least one characteristic, including pH, of CSF over time.

26. The apparatus of claim 25, wherein said catheter is a dual lumen catheter comprising a first lumen and a second lumen.

27. The apparatus of claim 26, wherein said sensor is housed in said first lumen and said CSF is withdrawn through said second lumen.

28. The apparatus of claim 25, wherein said characteristic monitored further includes a characteristic selected from the group consisting of partial oxygen pressure, temperature, carbon dioxide concentration, and combinations thereof.

29. The apparatus of claim 26, further comprising:

equipment for monitoring, storing, and, comparing data of said characteristic from said sensor over time.