Automated system for continuously and automatically calibrating electrochemical sensors
First Claim
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1. A method for automatic monitoring of a sensor comprising:
- (i) analyzing an analyte comprising a known concentration in a reference solution to determine a first measurement of said known concentration of the analyte in said reference solution;
(ii) analyzing said analyte in said reference solution to determine a second measurement of said known concentration of said analyte in said reference solution;
(iii) comparing said known concentration and said first measurement of said analyte;
(iv) comparing said known concentration and said second measurement of said analyte;
(v) comparing said first measurement and said second measurement of said analyte; and
(vi) initiating corrective action if said first measurement of said analyte is substantially similar to said second measurement of said analyte and said first and said second measurements are substantially dissimilar to said known concentration of said analyte.
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Abstract
An electrochemical sensor system that continuously monitors and calibrates the sensors included in the system. The invention also includes a method for determining failure patterns of a sensor and incorporating into an electrochemical sensor system the ability to recognize the failure pattern and initiate remedial action.
283 Citations
34 Claims
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1. A method for automatic monitoring of a sensor comprising:
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(i) analyzing an analyte comprising a known concentration in a reference solution to determine a first measurement of said known concentration of the analyte in said reference solution; (ii) analyzing said analyte in said reference solution to determine a second measurement of said known concentration of said analyte in said reference solution; (iii) comparing said known concentration and said first measurement of said analyte; (iv) comparing said known concentration and said second measurement of said analyte; (v) comparing said first measurement and said second measurement of said analyte; and (vi) initiating corrective action if said first measurement of said analyte is substantially similar to said second measurement of said analyte and said first and said second measurements are substantially dissimilar to said known concentration of said analyte. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method for measuring an analyte in a patient fluid sample comprising automatic monitoring of a sensor system for measuring the analyte concentration in the patient fluid sample, comprising:
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(i) analyzing an analyte comprising a known concentration in a reference solution to determine a first measurement of said known concentration of said analyte; (ii) analyzing said analyte in said reference solution to determine a second measurement of said known concentration of said analyte; (iii) comparing said known concentration and said first measurement of said analyte; (iv) comparing said known concentration and said second measurement of said analyte; (v) comparing said first measurement of said analyte and said second measurement of said analyte; and (vi) measuring said analyte concentration in said patient fluid sample if said first measurement of said analyte and said second measurement of said analyte are sufficiently dissimilar and said second measurement is sufficiently similar to said known concentration of said reference solution. - View Dependent Claims (10, 11, 12, 13, 14, 15)
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16. A sensor system comprising:
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(a) a reference solution comprising a known concentration of at least one analyte; (b) a sensor analyzing said analyte to determine a first measurement and a second measurement of said analyte in said reference solution; (c) a comparator comparing; (i) said known concentration and said first measurement; (ii) said known concentration and said second measurement; and (iii) said first measurement and said second measurement; and (d) a corrective action device initiating corrective action if said first measurement of said analyte in said reference solution is substantially similar to said second measurement of said analyte in said reference solution and said first and said second measurements are substantially dissimilar to said known concentration of said analyte in said reference solution. - View Dependent Claims (17, 18, 19, 20, 21)
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22. A sensor system comprising:
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(i) means for analyzing an analyte comprising a known concentration in a reference solution to determine a first measurement of said analyte in said reference solution; (ii) means for analyzing said analyte in said reference solution to determine a second measurement of said analyte in said reference solution; (iii) means for comparing said first measurement of said analyte and said second measurement of said analyte in said reference solution; (iv) means for comparing said first measurement of said analyte and said known concentration of said analyte; (v) means for comparing said second measurement of said analyte and said known concentration of said analyte; and (vi) means for initiating corrective action if said first measurement of said analyte is substantially similar to said second measurement of said analyte and said first and said second measurements are substantially dissimilar to said known concentration of said analyte in said internal reference solution.
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23. A method for monitoring performance of a sensor for analyzing at least a first and a second patient sample during use life of the sensor, the method comprising the steps of:
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(a) verifying the sensor performance during the use life of the sensor only once with an external solution before analyzing the a first patient sample; and
thereafter(b) verifying the sensor performance before analyzing the second patient sample using only an internal reference solution to monitor the sensor performance. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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Specification