Thiazolidine compounds and pharmaceutical compositions exhibiting thrombopoietin receptor agonism

  • US 7,026,334 B1
  • Filed: 07/24/2000
  • Issued: 04/11/2006
  • Est. Priority Date: 07/26/1999
  • Status: Expired due to Fees
First Claim
Patent Images

1. A compound represented by the formula (II):

  • embedded imageor its prodrug;

    or a pharmaceutically acceptable salt or solvate thereof, wherein X2 is an optionally substituted 5-member thiazole ring;

    Y2 is —

    NRGCO—

    (CH2)0-2

    , wherein RG is a hydrogen atom or an optionally substituted lower alkyl;

    Z2 is an optionally substituted phenylene;

    A2 is a thiazolidine ring represented by the formula;

    embedded imagewherein R1 and R2 are both hydrogen atoms or taken together may form an oxygen atom or a sulfur atom, R3 and R4 are both hydrogen atoms or taken together may form an oxygen atom or a sulfur atom, Q and V are chosen from —

    S—

    , and —

    NR—

    , wherein RB is a hydrogen atom or lower alkyl; and

    a broken line ( - - - ) represents the presence or absence of a bond.

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