Microneedle array systems

• US 7,027,478 B2
• Filed: 12/20/2001
• Issued: 04/11/2006
• Est. Priority Date: 12/21/2000
• Status: Expired due to Fees

• Current Assignee: Valeritas, Inc. (Zealand Pharma A/S)
• Original Assignee: Biovail Laboratories Incorporated (Bausch Health Cos., Inc.)
• Inventors: Ackley, Donald E.
• Primary Examiner(s): Harvey, Minsun Oh
• Assistant Examiner(s): Nguyen, Tuan N.
• Application Number:
  US10/027,115
• Publication Number:
  US 20030095582A1
• Time in Patent Office: 1,573 Days
• Field of Search: 385/89, 385/146, 385/137, 604/46, 604/22, 604/167, 716/8, 257/81, 372/108, 372/6
• US Class Current: 372/108
• CPC Class Codes: G02B 6/262 Optical details of coupling light into, or out of, or between fibre ends, e.g. special fibre end shapes or associated optical elements
• CPC Class Codes: G02B 6/382 with index-matching medium between light guides provisionally see G02B6/4212
• CPC Class Codes: G02B 6/3834 Means for centering or aligning the light guide within the ferrule
• CPC Class Codes: G02B 6/3861 Adhesive bonding adhesives in general C09J
• CPC Class Codes: G02B 6/3873 Connectors using guide surfaces for aligning ferrule ends, e.g. tubes, sleeves, V-grooves, rods, pins, balls
• CPC Class Codes: G02B 6/3874 using tubes, sleeves to align ferrules
• CPC Class Codes: G02B 6/3885 Multicore or multichannel optical connectors, i.e. one single ferrule containing more than one fibre, e.g. ribbon type optical ribbon cable G02B6/4403, G02B6/448
• CPC Class Codes: G02B 6/4203 Optical features
• CPC Class Codes: G02B 6/4232 using the surface tension of fluid solder to align the elements, e.g. solder bump techniques flip-chip mounting techniques in assembly of semiconductor devices H01L24/81
• CPC Class Codes: G02B 6/4249 comprising arrays of active devices and fibres

Abstract

The present invention relates to systems of microneedle arrays to align and form optical components. Active components such as lasers are combined with optical fibers. Microneedles are fabricated using techniques such as laser drilled Kapton, and combined with optical fiber, using bump bonding and UV curing adhesives to manufacture a variety of optical components.

Claims

1. An optical device comprising:

a plurality of needles having channels;

a plurality of fibers inserted in the plurality of needles;

and a plurality of optical components aligned and connected with the plurality of fibers,

wherein said channels for said needles are tapered, and wherein each of said needles has dimensions of about 125 micron exit hole at the narrower end, about 125 micron length, about 175–

200 micron entrance hole at the wider end, and about 250 micron between centers.

2. The optical device of claim 1 wherein the needles are microneedles.

3. The optical device of claim 1 wherein the optical components are vertical cavity surface emitting lasers.

4. The optical device of claim 1 wherein the optical components are photodetectors.

5. The optical device of claim 1 further comprising a plurality of photodetectors.

6. The optical device of claim 1 further comprising a sensing element.

7. The optical device of claim 6, wherein said sensing element comprises a matrix doped with calorimetric and/or fluorescent materials that are sensitive to environmental conditions.

8. The optical device of claim 7, wherein said calorimetric materials comprise environmentally sensitive dyes selected from rhodamines, bodipy dyes, ruthenium-based dyes, earth dyes, or metal intercalating dyes.

9. The optical device of claim 7, wherein said matrix is selected from:

sol gels, hydrogels, polymers with a high gas or liquid permeability, or a hydrophobic matrix.

10. The optical device of claim 6, wherein said sensing element is suitable for blood gas sensing, biological oxygen demand, or food safety.

11. The optical device of claim 6, wherein said sensing element is within or outside the tips of said needles.

12. The optical device of claim 1, wherein the narrowed end of said tapered channel is narrower than the diameter of said fibers.

13. The optical device of claim 1, wherein said needles are fabricated using photolithography and/or laser drilling.

14. The optical device of claim 1, wherein said needles have needle bore and needle placement accurate to about 1 micron.

15. The optical device of claim 1, wherein said fibers are fixed inside said needles.

16. The optical device of claim 15, wherein said fibers are fixed inside said needles with epoxy.

17. The optical device of claim 1, wherein said needles are made of metal.

18. The optical device of claim 1, further comprising a layer of transparent underfill between said plurality of needles with said plurality of fibers inserted therein, and said plurality of optical components.

19. The optical device of claim 1, wherein the void in said channels with said fibers inserted therein is filled with cured epoxy.

20. The optical device of claim 19, wherein a cured epoxy plug separates the narrower end of said needle or channel and the end of said fiber.

21. The optical device of claim 19, further comprising a cured epoxy lens outside the tip of said needle.

22. The optical device of claim 21, wherein said cured epoxy lens is spherical in shape.