Factor IX/factor IXa activating antibodies and antibody derivatives
DC CAFCFirst Claim
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1. An isolated antibody or antibody fragment thereof that binds Factor IX or Factor IXa and increases the procoagulant activity of Factor IXa.
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Abstract
An antibody or antibody derivative against factor IX/activated factor IX (FIXa) which increases the procoagulant activity of FIXa.
37 Citations
22 Claims
- 1. An isolated antibody or antibody fragment thereof that binds Factor IX or Factor IXa and increases the procoagulant activity of Factor IXa.
- 12. A hybridoma cell line secreting an antibody that binds Factor LX or Factor IXa and increases the procoagulant activity of Factor IXa.
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17. A method of obtaining an antibody that interacts with Factor IX or Factor IXa and increases the procoagulant activity of Factor IXa, comprising the steps of:
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immunizing an immunocompetent mouse with an antigen selected from the group consisting of FIX, FIXaα
, FIXaβ
or fragments thereof,isolating spleen cells of the immunized mouse, producing hybridoma cells, screening the hybridoma cell supernatants for an increase in the procoagulant activity of Factor IXa, isolating and purifying the antibody from a supernatant from the hybridoma cells which exhibit an increase in the procoagulant activity of Factor IXa.
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Specification