Drug delivery system

• US 7,059,348 B2
• Filed: 05/13/2003
• Issued: 06/13/2006
• Est. Priority Date: 05/13/2002
• Status: Expired due to Fees

• Current Assignee: Fluidigm Corporation
• Original Assignee: Fluidigm Corporation
• Inventors: Nat, Avtar S.
• Primary Examiner(s): Lucchesi, Nicholas D.
• Assistant Examiner(s): Maiorino, Roz
• Application Number:
  US10/438,282
• Publication Number:
  US 20050197652A1
• Time in Patent Office: 1,127 Days
• Field of Search: 604/891.1, 128/903, 137/597, 251/61.1
• US Class Current: 137/597
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61K 9/703 characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
• CPC Class Codes: Y10T 137/87249 Multiple inlet with multiple outlet
• CPC Class Codes: Y10T 137/88062 Coaxial oppositely directed seats

Abstract

An implantable drug delivery system has a housing, a collapsible reservoir, a microfabricated flow channel, and at least one magnet. The collapsible reservoir is disposed in the housing. The microfabricated flow channel is connected at one end to the collapsible reservoir and opens at an external surface of the housing. The magnet is disposed within the housing adjacent a membrane defining the flow channel and is movable in response to a magnetic force to deflect the membrane into the flow channel for inhibiting drug flow from the collapsible reservoir to the external surface of the housing, and for pumping drug flow from the collapsible reservoir to the external surface of the housing.

Claims

1. An implantable drug delivery system, comprising:

a housing;

a collapsible reservoir disposed in the housing;

a microfabricated flow channel connected at one end to the collapsible reservoir, and further opening at an external surface of the housing;

at least one magnet disposed within the housing adjacent a membrane defining the flow channel, the magnet being movable in response to a magnetic force to deflect the membrane into the flow channel for inhibiting drug flow from the collapsible reservoir to the external surface of the housing, and for pumping drug flow from the collapsible reservoir to the external surface of the housing,

wherein the at least one magnetic comprises;

three magnets disposed adjacent the membrane, the three magnets being capable of sequential activation, each collapsing the flow channel in a region adjacent thereto, thereby peristaltically pumping the drug through the flow channel.

2. The implantable drug delivery system recited in claim 1, further comprising an electromagnet disposed within the housing to provide the magnetic force.

3. The implantable drug delivery system recited in claim 2, further comprising a power source disposed within the housing and coupled with the electromagnet.

4. The implantable drug delivery system recited in claim 1, wherein a wall of the collapsible reservoir is adapted to collapse in response to vacuum that is created as drug is depleted from the reservoir and to take up space formely occupied by an expelled amount of drug.

5. The implantable drug delivery system recited in claim 1, further comprising an electromagnet disposed within the housing to provide the magnetic force.

6. The implantable drug delivery system recited in claim 5, further comprising a power source disposed within the housing and coupled with the electromagnet.

7. The implantable drug delivery system recited in claim 1, wherein a wall of the collapsible reservoir is adapted to collapse in response to vacuum that is created as drug is depleted from the reservoir and to take up space formely occupied by an expelled amount of drug.