Compositions containing antimicrobials and urea for the treatment of dermatological disorders and methods for their use

• US 7,067,556 B2
• Filed: 05/10/2002
• Issued: 06/27/2006
• Est. Priority Date: 09/24/2001
• Status: Expired due to Fees

• Current Assignee: Fougera Pharmaceuticals Incorporated (Novartis Ag)
• Original Assignee: Bradley Pharmaceuticals Incorporated (Novartis Ag)
• Inventors: Glassman, Daniel, Glassman, Bradley P., Bhagwat, Dileep
• Primary Examiner(s): KIM, VICKIE Y
• Application Number:
  US10/143,712
• Publication Number:
  US 20030064969A1
• Time in Patent Office: 1,509 Days
• Field of Search: 514/603, 514/588, 514/859
• US Class Current: 514/603
• CPC Class Codes: A61K 8/466 containing sulfonic acid derivatives; Salts
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/02 for chemically bleaching or whitening the skin
• CPC Class Codes: A61Q 5/00 Preparations for care of the hair
• CPC Class Codes: A61Q 9/00 Preparations for removing hair or for aiding hair removal

Abstract

Topical compositions which include urea and an antimicrobial agent, particularly sulfacetamide, are described. Sulfacetamide compositions further including sulfur are also described. Methods for treating dermatological disorders using the compositions are also described.

Claims

1. A method for treating a dermatological disorder selected from the group consisting of acne, psoriasis, seborrhea, rosacea, ingrown hairs, pseudofolliculitis barbae, and hyperpigmented skin comprising applying a topical composition consisting essentially of:

an amount of urea effective as an antimicrobial agent;

an amount of sulfacetamide or a salt thereof; and

a carrier wherein the amount of urea is from about 10 to about 40% by weight.

2. The method of claim 1, wherein the amount of sulfacetamide or a salt thereof is from about 5 to about 20% by weight.

3. The method of claim 1, wherein the dermatological disorder is acne.

4. The method of claim 2, wherein the dermatological disorder is acne.