Recombinant A2-specific TNFα specific antibodies

  • US 7,070,775 B2
  • Filed: 07/18/2002
  • Issued: 07/04/2006
  • Est. Priority Date: 03/18/1991
  • Status: Expired due to Fees
First Claim
Patent Images

1. An isolated recombinant anti-TNF-α

  • antibody or antigen-binding fragment thereof, said antibody comprising a human constant region, wherein said antibody or antigen binding fragment (i) competitively inhibits binding of A2 (ATCC Accession No. PTA-7045) to human TNF-α

    , and (ii) binds to a neutralizing epitope of human TNF-α

    in vivo with an affinity of at least 1×

    108 liter/mole, measured as an association constant (Ka), as determined by Scatchard analysis.

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