Cytokine receptor

• US 7,071,308 B2
• Filed: 08/25/2004
• Issued: 07/04/2006
• Est. Priority Date: 11/10/2000
• Status: Expired due to Term

• Current Assignee: Merck Sharp & Dohme Corporation (Merck & Co., Inc.)
• Original Assignee: Schering Corporation (Merck & Co., Inc.)
• Inventors: Soumelis, Vassilli, de Waal Malefyt, Rene, Liu, Yong-Jun, Bazan, J. Fernando, Kastelein, Robert A., Reche-Gallardo, Pedro A.
• Primary Examiner(s): MERTZ, PREMA MARIA
• Application Number:
  US10/927,228
• Publication Number:
  US 20050014199A1
• Time in Patent Office: 678 Days
• Field of Search: None
• US Class Current: 530/350
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: C07K 14/54 Interleukins [IL]
• CPC Class Codes: C07K 14/7155 for interleukins [IL]
• CPC Class Codes: C07K 16/244 Interleukins [IL]
• CPC Class Codes: G01N 2333/54 Interleukins [IL]
• CPC Class Codes: G01N 2500/02 Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
• CPC Class Codes: G01N 33/6863 Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
• CPC Class Codes: G01N 33/6869 Interleukin

Abstract

Nucleic acids encoding mammalian cytokine receptor, e.g., for cytokine IL-B50, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.

Claims

1. An isolated or purified heterodimeric receptor complex comprising a polypeptide of the amino acids as set forth in SEQ ID NO:

2 and a polypeptide of the amino acids as set forth in SEQ ID NO;

4.

2. The receptor complex of claim 1 that specifically binds a polypeptide of amino acids 1–

131 as set forth in SEQ ID NO;

6.