Cosmetic and pharmaceutical oil-in-water emulsions

• US 7,074,419 B2
• Filed: 02/06/2001
• Issued: 07/11/2006
• Est. Priority Date: 02/19/2000
• Status: Expired due to Term

• Current Assignee: Evonik Degussa GmbH
• Original Assignee: Evonik Goldschmidt GmbH (Rag-Stiftung)
• Inventors: Jenni, Klaus, Hameyer, Peter, Dietz, Thomas
• Primary Examiner(s): Wang, Shengjun
• Application Number:
  US09/777,544
• Publication Number:
  US 20010046507A1
• Time in Patent Office: 1,981 Days
• Field of Search: 424/401, 424/70.11, 424/70.12
• US Class Current: 424/401
• CPC Class Codes: A61K 8/06 Emulsions
• CPC Class Codes: A61K 8/062 Oil-in-water emulsions
• CPC Class Codes: A61K 8/342 Alcohols having more than seven atoms in an unbroken chain
• CPC Class Codes: A61K 8/37 Esters of carboxylic acids
• CPC Class Codes: A61K 8/375 the alcohol moiety containing more than one hydroxy group
• CPC Class Codes: A61K 8/894 modified by a polyoxyalkylene group, e.g. cetyl dimethicone copolyol
• CPC Class Codes: A61P 17/16 Emollients or protectives, e.g. against radiation
• CPC Class Codes: A61Q 17/04 Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin

Abstract

The present invention relates to the use of a polyether-modified polysiloxanes of a defined structure for the preparation of cosmetic and pharmaceutical oil-in-water emulsions, and to oil-in-water emulsions which comprise said polysiloxanes.

Claims

1. A cosmetic or pharmaceutical oil-in-water emulsion which comprises at least one polyether siloxane of the general formula (I)

R(CH₃)₂SiO—

[(CH₃)₂SiO]_n—

Si(CH₃)₂R 

 

(I)

where

n=50 to 250

R=—

(CH₂)_m—

O—

(C₂H₄O)_x—

(C₃H₆O)_yR¹

m=2 to 4

x=3 to 100

y=0 to 50

R¹=H, CH₃, or CH₂CH₃,

having a proportion by weight of the polyether radicals R of up to 45%, by weight, of the total molecular mass; and

at least one stabilizer selected from the group consisting of a liquid-crystalline-structure forming hydrophilic wax, a water-swellable organopolymer, and a mixture of a liquid-crystalline-structure forming hydrophilic wax and a water swellable organopolymer, wherein said oil-in-water emulsion is free of silicone oils.

2. The cosmetic or pharmaceutical oil-in-water emulsion of claim 1 further comprising at least one coemulsifier.

3. The cosmetic or pharmaceutical oil-in-water emulsion of claim 2 wherein said at least one stabilizer is said hydrophilic wax.

4. The cosmetic or pharmaceutical oil-in-water emulsion of claim 3 wherein said hydrophilic wax is selected from the group consisting of stearyl alcohol, stearic acid, glyceryl stearate and mixtures thereof.

5. The cosmetic or pharmaceutical oil-in-water emulsion of claim 2, wherein the proportion of the polyether siloxane of the general formula (I), in the case of the presence of coemulsifiers is, based on the total amount of the emulsifiers, at least 50% by weight.

6. The cosmetic or pharmaceutical oil-in-water emulsion of claim 5 wherein the proportion of polyether siloxane is 65 to 95%, by weight.

7. The cosmetic or pharmaceutical oil-in-water emulsion of claim 2 wherein the proportion of the coemulsifier of the total amount of the emulsifiers is 5 to 49%, by weight.

8. The cosmetic or pharmaceutical oil-in-water emulsion of claim 7 wherein said proportion is from 10 to 350%, by weight.

9. The cosmetic or pharmaceutical oil-in-water emulsion of claim 1 further comprising auxiliaries and additives selected from the group consisting of UV light protecting filters, antioxidants, preservatives, insect repellents, self-tanning agents, perfume oils, dyes and active ingredients.

10. A process of preparing an oil-in-water emulsion comprising:

emulsifying a silicone oil-free oil phase in a water phase with at least one polyether siloxane of the general formula (I)

R(CH₃)₂SiO—

[(CH₃)₂SiO]_n—

Si(CH₃)₂R 

 

(I)

where

n=50 to 250

R=—

(CH₂)_m—

O—

(C₂H₄O)_x—

(C₃H₆O)_yR¹

m=2 to 4

x=3 to 100

y=0 to 50

R¹=H, CH₃, or CH₂CH₃,

having a proportion by weight of the polyether radicals R of up to 45% of the total molecular mass, and at least one stabilizer selected from the group consisting of liquid-crystalline-structure forming hydrophilic waxes, water swellable organopolymers and combinations thereof to provide an emulsion.

11. The process of claim 10 wherein said oil-in-water emulsion further comprises a coemulsifier.

12. The process of claim 10 wherein said at least one stabilizer is said hydrophilic wax which is selected from the group consisting of stearyl alcohol, stearic acid, glyceryl stearate and mixtures thereof.

13. A cosmetic or pharmaceutical oil-in-water emulsion which comprises 10 weight percent or less of a monohydric alcohol;

and at least one polyether siloxane of the genial formula (I)

R(CH₃)₂SiO—

[(CH₃)₂SiO]_n—

Si(CH₃)₂R 

 

(I)

where

n=50 to 250

R=—

(CH₂)_m—

O—

(C₂H₄O)_x—

(C₃H₆O)_yR¹

m=2 to 4

x=3 to 100

y=0 to 50

R¹=H, CH₃, or CH₂CH₃,

having a proportion by weight of the polyether radicals R of up to 45%, by weight, of the total molecular mass, and at least one stabilizer selected from the group consisting of a liquid-crystalline-structure forming hydrophilic wax, a water-swellable organopolymer, and a mixture of a liquid-crystalline-structure forming hydrophilic wax and a water swellable organopolymer, wherein said oil-in-water emulsion is free of silicone oils.

14. The cosmetic or pharmaceutical oil-in-water emulsion of claim 13 further comprising at least one coemulsifier.

15. The cosmetic or pharmaceutical oil-in-water emulsion of claim 14 wherein said at least one stabilizer is said hydrophilic wax.

16. The cosmetic or pharmaceutical oil-in-water emulsion of claim 15 wherein said hydrophilic wax is selected from the group consisting of stearyl alcohol, stearic acid, glyceryl stearate and mixtures thereof.

17. The cosmetic or pharmaceutical oil-in-water emulsion of claim 14, wherein the proportion of the polyether siloxane of the general formula (I), in the case of the presence of coemulsifiers is, based on the total amount of the emulsifiers, at least 50% by weight.

18. The cosmetic or pharmaceutical oil-in-water emulsion of claim 17 wherein the proportional of polyether siloxane is 65 to 95%, by weight.

19. The cosmetic or pharmaceutical oil-in-water emulsion of claim 14 wherein the proportion of the coemulsifier of the total amount of the emulsifiers is 5 to 49%, by weight.