Process for reducing mineralization of tissue used in transplantation
First Claim
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1. A method for making an implantable vascular bioprosthesis, the method comprisingexcising tissue from an animal, the excised tissue selected from the group consisting of porcine aortic root tissue, bovine aortic root tissue, porcine pericardium, bovine pericardium, bovine veins, porcine veins, bovine arteries, and porcine arteries;
- and removing cell debris from the excised tissue by a method which comprises;
contacting the excised tissue with a composition comprising at least one oxidizing agent prior to significant degradation of the excised tissue;
rinsing the oxidizing agent-contacted tissue to remove at least a portion of the oxidizing agent wherein the rinsing step comprises;
contacting the excised tissue with a non-ionic detergent composition and contacting the excised tissue with a second, ionic detergent composition.
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Abstract
A method of making a tissue-derived implantable medical device that includes contacting the tissue with a composition comprising at least one oxidizing agent prior to implantation of the medical device.
186 Citations
29 Claims
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1. A method for making an implantable vascular bioprosthesis, the method comprising
excising tissue from an animal, the excised tissue selected from the group consisting of porcine aortic root tissue, bovine aortic root tissue, porcine pericardium, bovine pericardium, bovine veins, porcine veins, bovine arteries, and porcine arteries; - and removing cell debris from the excised tissue by a method which comprises;
contacting the excised tissue with a composition comprising at least one oxidizing agent prior to significant degradation of the excised tissue;
rinsing the oxidizing agent-contacted tissue to remove at least a portion of the oxidizing agent wherein the rinsing step comprises;
contacting the excised tissue with a non-ionic detergent composition and contacting the excised tissue with a second, ionic detergent composition. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
- and removing cell debris from the excised tissue by a method which comprises;
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15. A method of making a tissue-derived heart valve bioprosthesis, the method comprising:
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excising heart valve tissue from an animal, the excised tissue including valvular leaflets and supporting structure; and removing cell debris from the excised tissue by a method which comprises;
contacting the excised tissue with a composition comprising at least one oxidizing agent prior to significant degradation of the excised tissue; and
rinsing the oxidizing agent-contacted tissue to remove at least a portion of the oxidizing agent wherein the rinsing step comprises;
contacting the excised tissue with a non-ionic detergent composition and contacting the excised tissue with a second, ionic detergent composition. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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Specification