Compositions and methods for minimizing adverse drug experiences associated with oxybutynin therapy

  • US 7,081,252 B2
  • Filed: 12/08/2003
  • Issued: 07/25/2006
  • Est. Priority Date: 04/26/2000
  • Status: Active Grant
First Claim
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1. A method of treating with oxybutynin a human subject having overactive bladder, while minimizing an anticholinergic or antimuscarinic adverse drug experience associated with said oxybutynin treatment therapy comprising the step of:

  • administering as a transdermal patch, a composition comprising oxybutynin to said subject for a duration of from about 24 to about 96 hours to provide a plasma area under the curve (AUC) ratio of oxybutynin to an oxybutynin metabolite of from about 0.5;

    1 to about 5;

    1, wherein the transdermal patch optionally includes a permeation enhancer.

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