Methods and compositions for the targeted delivery of biologically active agents

  • US 7,097,857 B2
  • Filed: 01/14/2003
  • Issued: 08/29/2006
  • Est. Priority Date: 08/23/2000
  • Status: Expired due to Fees
First Claim
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1. A method for the systemic delivery of an effective amount of a labile agent to a mammal comprising orally administering to the mammal an effective amount of a sustained release composition comprising microparticles containing a labile agent, a biocompatible polymer, and a water soluble polymer wherein, the microparticles have a number median diameter of greater than 20 microns, the water soluble polymer represents at least about 20% of the dry weight of the microparticles and the microparticles generate pseudo-microparticles upon hydration, whereby sufficient pseudo-microparticles are absorbed into the Peyer'"'"'s patches of the gastrointenstinal tract.

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