Isolation of a dual cox-2 and 5-lipoxygenase inhibitor from acacia

• US 7,108,868 B2
• Filed: 03/22/2002
• Issued: 09/19/2006
• Est. Priority Date: 03/22/2002
• Status: Expired due to Term

• Current Assignee: Unigen Corporation
• Original Assignee: Unigen Pharmaceuticals (ECONET, Incorporated)
• Inventors: Waite, Scott, Nichols, Timothy C., Jia, Qi, Rhoden, Eric
• Primary Examiner(s): MELLER, MICHAEL V
• Application Number:
  US10/104,477
• Publication Number:
  US 20030180402A1
• Time in Patent Office: 1,642 Days
• Field of Search: 424/725
• US Class Current: 424/725
• CPC Class Codes: A61K 31/33 Heterocyclic compounds
• CPC Class Codes: A61K 31/353 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
• CPC Class Codes: A61K 36/00 Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines antigens from pollen A61K39/36
• CPC Class Codes: A61K 36/48 Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 15/08 for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 17/06 Antipsoriatics
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/04 Centrally acting analgesics, e.g. opioids
• CPC Class Codes: A61P 25/06 Antimigraine agents
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 37/02 Immunomodulators
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The present invention provides a novel method for simultaneously inhibiting the cyclooxygenase COX-2 and 5-lipoxygenase (5-LO) enzymes. The method for the simultaneous dual inhibition of COX-2 and 5-LO is comprised of administering a composition containing an individual and/or a mixture of multiple flavans isolated from a single plant or multiple plants in the Acacia genus of plants to a host in need thereof. The present also includes novel methods for the prevention and treatment of COX-2 and 5-LO mediated diseases and conditions. The method for preventing and treating COX-2 and 5-LO mediated diseases and conditions is comprised of administering to a host in need thereof an effective amount of a composition comprising an individual and/or a mixture of multiple flavans isolated from a single plant or multiple plants in the Acacia genus of plants and a pharmaceutically acceptable carrier. The present invention includes a method for isolating and purifying a composition of flavans having dual specificity for COX-2 and 5-LO from the Acacia genus of plants.

Claims

1. A method for the treatment of a COX-2 and 5-lipoxygenase (5-LO) mediated inflammatory condition comprising administering to a patient in need thereof an isolated and purified pharmaceutical composition comprising an organic extract from Acacia catechu;

wherein said extract is isolated by a method comprising;

a) extracting the ground biomass Acacia catechu;

and

b) purifying said extract obtained from step a) to obtain an extract comprised of a mixture of flavans, said mixture of flavans consisting essentially of catechin and epicatechin.

2. The method of claim 1 wherein said mixture of flavans is isolated from a plant part.

3. The method of claim 2 wherein the plant part is selected from the group consisting of stems, stem barks, trunks, trunk barks, twigs, tubers, roots, root barks, young shoots, seeds, rhizomes, flowers and other reproductive organs, leaves and other aerial parts.

4. A method for the treatment of a COX-2 and 5-lipoxygenase (5-LO) mediated inflammatory condition comprising administering to a patien in need thereof an isolated and purified pharmaceutical composition comprising an organic extract of Acacia catechu wherein said extract is comprised of a mixture of flavans, said mixture of flavans consisting essentially of catechin and epicatechin.

5. The method of claim 4 wherein said mixture of flavans is isolated from a plant part.

6. The method of claim 5 wherein the plant part is selected from the group consisting of stems, stem barks, trunks, trunk barks, twigs, tubers, roots, root barks, young shoots, seeds, rhizomes, flowers and other reproductive organs, leaves and other aerial parts.