Tissue electroperforation for enhanced drug delivery

  • US 7,113,821 B1
  • Filed: 08/23/2000
  • Issued: 09/26/2006
  • Est. Priority Date: 08/25/1999
  • Status: Expired due to Term
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First Claim
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1. A method for transporting a molecule through a mammalian barrier membrane of at least one layer of cells comprising the steps of:

  • creating an air gap between a treatment electrode and said membrane;

    then ablating said membrane with an electric current from said treatment electrode wherein said electric current forms an electric arc within said air gap between said treatment electrode and said membrane; and

    utilizing a driving force to move said molecule through said ablated membrane, wherein said membrane is skin or a mucosal membrane.

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  • 4 Assignments
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