Protein kinase inhibitors

• US 7,122,550 B2
• Filed: 05/23/2003
• Issued: 10/17/2006
• Est. Priority Date: 05/23/2002
• Status: Expired due to Term

• Current Assignee: YM BioSciences Australia Pty Ltd (Gilead Sciences Inc.)
• Original Assignee: Cytopia Pty Ltd. (Gilead Sciences Inc.)
• Inventors: Wilks, Andrew Frederick, Burns, Christopher John, Bu, Xianyong
• Primary Examiner(s): Wilson, James O.
• Assistant Examiner(s): Tucker, Zachary C.
• Application Number:
  US10/469,303
• Publication Number:
  US 20040235862A1
• Time in Patent Office: 1,243 Days
• Field of Search: None
• US Class Current: 514/255.05
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/06 Antipsoriatics
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 21/00 Drugs for disorders of the muscular or neuromuscular system
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 31/14 for RNA viruses
• CPC Class Codes: A61P 31/18 for HIV
• CPC Class Codes: A61P 31/20 for DNA viruses
• CPC Class Codes: A61P 31/22 for herpes viruses
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 35/02 specific for leukemia
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 37/02 Immunomodulators
• CPC Class Codes: A61P 37/08 Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07D 241/20 : Nitrogen atoms nitro radicals C07D241/16
• CPC Class Codes: C07D 401/12 : linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 405/12 : linked by a chain containing hetero atoms as chain links

Abstract

A compound of the general formula:

or pharmaceutically acceptable salts, hydrates, solvates, crystal forms of diastereomers thereof is described. A method of treating protein kinase-associated disease states using the compound of Formula I is also described.

Claims

1. A compound of the general formula

2. A compound according to claim 1 selected from compounds of the general formula II:

3. A compound according to claim 1 where W is C_1-4 alkyl wherein the compound possesses S chirality at the chiral carbon bearing W.

4. A compound according to claim 3 wherein the compound is a mixture of R and S isomers and the mixture comprises at least 70% of the S isomer.

5. A compound according to claim 4 wherein the compound comprises at least 80% of the S isomer.

6. A compound according to claim 4 wherein the compound comprises at least 90% of the S isomer.

7. A compound according to claim 4 wherein the compound comprises at least 95% of the S isomer.

8. A compound according to claim 4 wherein the compound comprises at least 99% of the S isomer.

9. A compound according to claim 1 wherein the compound is selected from the group consisting of:

10. A composition comprising a carrier and at least one compound according to claim 1.

11. A pharmaceutical composition comprising at least one of the compounds according to claim 1 and a pharmaceutically acceptable vehicle or diluent.