Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation

• US 7,131,987 B2
• Filed: 05/24/2002
• Issued: 11/07/2006
• Est. Priority Date: 10/16/2000
• Status: Expired due to Term

• Current Assignee: Corium Pharma Solutions, Inc.
• Original Assignee: Corium International, Inc.
• Inventors: Gartstein, Vladimir, Sherman, Faiz Feisal
• Primary Examiner(s): Nguyen, Anh Tuan
• Assistant Examiner(s): NGUYEN, VI X
• Application Number:
  US10/154,686
• Publication Number:
  US 20020177858A1
• Time in Patent Office: 1,628 Days
• Field of Search: 600/556, 604/46, 604/47, 604/48, 604/289, 604/290, 606/131, 606/132, 606/133
• US Class Current: 604/290
• CPC Class Codes: A45D 26/0004 by abrasion
• CPC Class Codes: A61B 17/205 Vaccinating by means of needles or other puncturing devices
• CPC Class Codes: A61B 17/322 Skin grafting apparatus
• CPC Class Codes: A61B 17/54 Chiropodists' instruments , e.g. pedicure chiropractic devices A61H1/008
• CPC Class Codes: A61B 2017/00761 Removing layer of skin tissue, e.g. wrinkles, scars or cancerous tissue
• CPC Class Codes: A61B 2017/00765 Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
• CPC Class Codes: A61B 2017/320008 Scrapers
• CPC Class Codes: A61M 2037/0023 Drug applicators using microneedles
• CPC Class Codes: A61M 2037/003 having a lumen
• CPC Class Codes: A61M 2037/0038 having a channel at the side surface
• CPC Class Codes: A61M 2037/0046 Solid microneedles
• CPC Class Codes: A61M 2037/0053 Methods for producing microneedles
• CPC Class Codes: A61M 37/0015 by using microneedles

Abstract

An improved method is provided to enhance skin appearance and health, in which skin is cleaned (or exfoliated) and conditioned by use of microelements affixed to a base element or hand-held patch. For the microstructure used in the improved method, the dimensions of the microelements are controlled so as to remove a certain number of layers of skin cells and to accumulate and retain those skin cells, along with other foreign substances, into areas between the microelements. In another embodiment of the improved method, a conditioning compound or therapeutic active can be applied to the exfoliated skin to enhance the skin. Moreover, the amount of skin cells accumulated using the improved method represents a self-limiting maximum quantity that cannot be substantially exceeded regardless of the number of attempts by a user to re-use the microstructure apparatus associated with the improved method. Some of the microelement shapes are purposefully designed with distal ends that exhibit sharp edges rather than sharp tips to reduce skin irritation resulting from use of the improved method.

Claims

1. A method for removing cells from skin, said method comprising:

(a) providing a microstructure having a substrate and a plurality of microelements, wherein a majority of said microelements are of at least one predetermined shape that includes at least one substantially sharp edge at a distal end of the microelements;

(b) placing said microstructure on skin then rubbing the microstructure against said skin, thereby scraping and accumulating skin cells on said substrate in areas between said plurality of microelements, wherein said at least one predetermined shape of said majority of microelements does not create substantial focal discrete points of pressure on skin; and

(c) withdrawing said microstructure from said skin, and thereby removing a large majority of said skin cells that have accumulated and are retained upon said substrate.

2. The method as recited in claim 1, wherein during said step of rubbing the microstructure against the skin, vellus hair is also removed along with skin cells.

3. The method as recited in claim 1, wherein said majority of microelements have a length and shape that tend to scrape skin cells loose without penetrating entirely through a stratum corneum layer of skin.

4. The method as recited in claim 1, wherein said microstructure is coated so as to act as a feedback indicator during use.

5. A method for removing cells from skin, said method comprising:

(a) providing a microstructure having a substrate and a plurality of inverted microelements, wherein a majority of said microelements extends from a first surface of said substrate and which exhibit a substantially empty space within said microelements, and wherein said majority of microelements exhibits at least one substantially sharp edge along a second surface of said substrate, said second surface being opposite the first surface of said substrate;

(b) placing the second surface of said microstructure on skin and then rubbing the microstructure against said skin, thereby scraping and accumulating skin cells within said substantially empty space within said majority of microelements; and

(c) withdrawing said microstructure from said skin, and thereby removing a large majority of said skin cells that have accumulated and are retained within said substantially empty space within said majority of microelements.

6. The method as recited in claim 5, wherein said microstructure is coated so as to act as a feedback indicator during use.

7. A method for removing cells from skin, said method comprising:

(a) providing a microstructure having a substrate and a plurality of microelements, wherein a majority of said microelements are of at least one predetermined size and shape, and each exhibit at least one side wall that extends above said first surface of the substrate, and wherein said majority of microelements are oriented in a closely-packed arrangement such that any spacing between portions of said side walls of adjacent microelements is substantially minimized;

(b) placing said microstructure on skin then rubbing the microstructure against said skin, thereby scraping and accumulating skin cells in areas between said majority of microelements; and

(c) withdrawing said microstructure from said skin, and thereby removing a large majority of said skin cells that have accumulated and are retained upon said microstructure.

8. The method as recited in claim 7, wherein said majority of microelements exhibits at least one substantially sharp edge and does not create substantial focal discrete points of pressure on skin.

9. The method as recited in claim 7, wherein said majority of microelements have a length and shape that tend to scrape skin cells loose without penetrating entirely through a stratum corneum layer of skin.