Methods of determining the concentration of an analyte in a fluid test sample
First Claim
1. A method of determining the concentration of an analyte in a fluid test sample, the method comprising the acts of:
- providing an electrochemical sensor adapted to measure the analyte in the fluid test sample, the electrochemical sensor having a counter electrode and a working electrode;
sufficiently covering the counter and working electrodes of the electrochemical sensor with the fluid test sample;
applying a first potential between the counter electrode and working electrode for a first predetermined time period;
measuring the current between the counter electrode and working electrode at a plurality of intervals during the first predetermined time period;
recording the times of at least one measurement during the first predetermined time period;
removing or substantially reducing the first potential between the counter electrode and working electrode for a second predetermined time period;
applying a second potential between the counter electrode and working electrode for a third predetermined time period;
measuring the current between the counter electrode and working electrode at least once during the third predetermined time period;
determining the concentration of the analyte in the fluid test sample as a function of the current measured;
calculating an index as a mathematical function of the following variables;
a measured current of the first predetermined time period a recorded time of the first predetermined time period, and a measured current of the third predetermined time period;
comparing the index to at least one predetermined parameter related to the determined concentration of analyte in the fluid test sample to identify when a bias, if any, exceeds a predetermined threshold; and
displaying either an error signal or an analyte concentration depending on the comparison between the index and the at least one predetermined parameter.
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Abstract
A method of determining the concentration of an analyte in a fluid test sample that includes providing an electrochemical sensor adapted to measure the analyte in the test sample. The test sample sufficiently covers a counter and working electrode of the electrochemical sensor. A first potential is applied between the counter and working electrodes for a first predetermined time period and the current is measured and the time is recorded. After the first potential is removed or substantially reduced, a second potential is applied between the counter and working electrodes and the current is measured. The concentration of the analyte is determined in the test sample as a function of the current measured. An index is calculated and compared to at least one predetermined parameter to identify when a bias, if any, exceeds a threshold. An error signal or analyte concentration is displayed depending on the comparison.
221 Citations
28 Claims
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1. A method of determining the concentration of an analyte in a fluid test sample, the method comprising the acts of:
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providing an electrochemical sensor adapted to measure the analyte in the fluid test sample, the electrochemical sensor having a counter electrode and a working electrode; sufficiently covering the counter and working electrodes of the electrochemical sensor with the fluid test sample; applying a first potential between the counter electrode and working electrode for a first predetermined time period; measuring the current between the counter electrode and working electrode at a plurality of intervals during the first predetermined time period; recording the times of at least one measurement during the first predetermined time period; removing or substantially reducing the first potential between the counter electrode and working electrode for a second predetermined time period; applying a second potential between the counter electrode and working electrode for a third predetermined time period; measuring the current between the counter electrode and working electrode at least once during the third predetermined time period; determining the concentration of the analyte in the fluid test sample as a function of the current measured; calculating an index as a mathematical function of the following variables;
a measured current of the first predetermined time period a recorded time of the first predetermined time period, and a measured current of the third predetermined time period;comparing the index to at least one predetermined parameter related to the determined concentration of analyte in the fluid test sample to identify when a bias, if any, exceeds a predetermined threshold; and displaying either an error signal or an analyte concentration depending on the comparison between the index and the at least one predetermined parameter. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A method of determining the concentration of an analyte in a fluid test sample, the method comprising the acts of:
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providing an electrochemical sensor adapted to measure the analyte in the fluid test sample, the electrochemical sensor having a counter electrode and a working electrode; sufficiently covering the counter and working electrodes of the electrochemical sensor with the fluid test sample; applying a first potential between the counter electrode and working electrode for a first predetermined time period; measuring the current between the counter electrode and working electrode at least once during the first predetermined time period; recording the times of the at least one measurement during the first predetermined time period; removing or substantially reducing the first potential between the counter electrode and working electrode for a second predetermined time period; applying a second potential between the counter electrode and working electrode for a third predetermined time period; measuring the current between the counter electrode and working electrode at least once during the third predetermined time period; determining the concentration of the analyte in the fluid test sample as a function of the current measured; calculating an index (I) by solving the equation;
I=(Irt/Ibmax)*Tbmaxwhere Irt=a selected measurement of the current during the third predetermined time period, Ibmax=the highest current measured during the first predetermined time period, and Tbmax=the time of the highest measured current is measured during the first predetermined time period; comparing the index to at least one predetermined parameter related to the determined concentration of analyte in the fluid test sample to identify when a bias, if any, exceeds a predetermined threshold; and displaying either an error signal or an analyte concentration depending on the comparison between the index and the at least one predetermined parameter. - View Dependent Claims (23, 24, 25)
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26. A method of determining the concentration of an analyte in a fluid test sample, the method comprising the acts of:
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providing an electrochemical sensor adapted to measure the analyte in the fluid test sample, the electrochemical sensor having a counter electrode and a working electrode; sufficiently covering the counter and working electrodes of the electrochemical sensor with the fluid test sample; applying a first potential between the counter electrode and working electrode for a first predetermined time period; measuring the current between the counter electrode and working electrode at a plurality of times during the first predetermined time period; recording the time of at least one measurement during the first predetermined time period; removing or substantially reducing the first potential between the counter electrode and working electrode for a second predetermined time period; applying a second potential between the counter electrode and working electrode for a third predetermined time period; measuring the current between the counter electrode and working electrode at least one during the third predetermined time period, determining the concentration of the analyte in the fluid test sample as a function of the current measured; calculating an index as a mathematical function of the following variables;
a recorded time of the first predetermined time period, and a measured current of the third predetermined time period;comparing the index to at least one predetermined parameter related to the determined concentration of analyte in the fluid test sample to identify when a bias, if any, exceeds a predetermined threshold; and displaying either an error signal or an analyte concentration depending on the comparison between the index and the at least one predetermined parameter. - View Dependent Claims (27, 28)
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Specification