Method and device for analyzing a periodic or semi-periodic signal

• US 7,151,957 B2
• Filed: 12/28/2000
• Issued: 12/19/2006
• Est. Priority Date: 12/29/1999
• Status: Active Grant

• Current Assignee: Bsp Biological Signal Processing Ltd.
• Original Assignee: Bsp Biological Signal Processing Ltd.
• Inventors: Beker, Amir, Hasson, Assaf, Ben David, Tamir
• Primary Examiner(s): Bockelman, Mark
• Application Number:
  US10/168,673
• Publication Number:
  US 20030208129A1
• Time in Patent Office: 2,182 Days
• Field of Search: 600/509, 600/517, 702189-190, 702/199
• US Class Current: 600/509
• CPC Class Codes: A61B 5/366 Detecting abnormal QRS complex, e.g. widening

Abstract

A device for reducing noise in signals having successive substantially repetitive portions, comprising: an iterative averager operative to superimpose and average said substantially repetitive portions to produce a running average thereof, and an iteration ender comprising a noise analyzer for determining a noise level in said running average and ending operation of said iterative averager when said noise level reaches a predetermined level. Also, a method of obtaining an indication of ischemia in a patient using an ECG signal therefrom, the method comprising: extracting an ECG signal over a duration, extracting from said ECG signal a series of QRS complexes over said duration, extracting high frequency components of said QRS complexes, analyzing said high frequency components over said duration for at least one of a predetermined quality, and inferring from said predetermined quality an indication of ischemia.

Claims

1. A device for reducing noise in signals having successive substantially repetitive portions, comprising:

an iterative averager operative to superimpose and average said substantially repetitive portions to produce a running average thereof,

an iteration ender comprising a noise analyzer for determining a noise level in said running average and ending operation of said iterative averager when a noise level reaches a predetermined level,

an aligner for aligning at least some of said substantially repetitive portions one with another,

wherein said signal comprises

first frequency and second frequency components and said aligner comprises a first frequency correlated band pass filter and a second frequency correlated band pass filter to extract respective first and second frequency components, thereby to use said first frequency components to locate an alignment point in successive portions and to use said alignment point to align said second frequency components.

2. A device for reducing noise in signals according to claim 1, wherein said iterative averager is operative to take said successive portions in successive iterative steps.

3. A device for reducing noise in signals according to claim 1, wherein said iteration ender is further operative to end said operation of said iterative averager when said repetitive portions are exhausted.

4. A device for reducing noise in signals according to claim 1, wherein said iteration ender is further operative to end said operation of said iterative averager when said running average reaches a preset maximum of included repetitive portions.

5. A device for reducing noise in signals according to claim 1, further comprising a repetitive portion selector for selecting repetitive portions for passing to said iterative averager, the repetitive portion selector comprising

a reference portion store for storing a reference portion,

a cross correlator for computing a cross correlation between a current repetitive portion and said reference portion, and

a comparator for comparing a result of said cross-correlation with a predetermined threshold to produce a comparison output,

and wherein said selector is operable to pass said current repetitive portion to said iterative averager in accordance with said comparison output.

6. A device for reducing noise in signals according to claim 5, further comprising a reference portion determination unit associated with said repetitive portion selector, operable to determine as a reference portion any one of a group comprising a first repetitive portion of a current length of said signal, a final result of a running average of a previous set of iterations and a prior determined typical wave.

7. A device for reducing noise in signals according to claim 6, wherein said reference portion determination unit is operable to dynamically change between members of said group over the course of a set of iterations.

8. A device for reducing noise in signals according to claim 6, wherein said reference portion determination unit further comprises a reference portion updater for dynamically updating said reference portion during the course of a set of iterations.

9. A device for noise reduction in a signal according to claim 1, further comprising a signal extractor for extracting said repetitive portion.

10. A device for noise reduction in a signal according to claim 9 comprising an RMS computation unit for calculation of the energy level of segments of wave obtained by averaging a series of said repetitive portions.

11. A device for noise reduction in a signal according to claim 10, further comprising an RMS value analysis unit for detecting a falloff in said RMS energy value over succeeding averages.

12. A device for noise reduction in a signal according to claim 9, comprising a cross-correlation unit for computing the cross correlation coefficient of an average of a series of said repetitive portions and a reference wave.

13. A device for noise reduction in a signal according to claim 12, further comprising a cross-correlation value analysis unit for detecting a falloff in said cross-correlation value over succeeding averages.

14. A device for noise reduction in a signal according to claim 1, wherein said aligner further comprises a cross-correlator for cross-correlating a current input with said running average at a plurality of successive alignments and for aligning said signal on the basis of an alignment giving a maximum cross-correlation.

15. A device for noise reduction in a signal according to claim 14 wherein said aligner further comprises:

an interpolator for interpolating between said cross-correlations at said successive alignments to determine a higher accuracy sub-sample alignment, and a wave shifter for shifting said current input in accordance with said determined sub-sample alignment.

16. A device for reducing noise in signals having successive substantially repetitive portions, comprising:

a repetitive portion selector for selecting repetitive portions for passing to an iterative averager, the repetitive portion selector comprising;

a reference portion store for storing said reference portion,

a first cross correlator for computing cross correlation between current repetitive portion and said reference portion,

a comparator for comparing a result of said cross-correlation with a predetermined threshold to produce a comparison output,

said iterative averager operative to superimpose and average said substantially repetitive portions to produce running average thereof,

an iteration ender comprising a noise analyzer for determining a noise level in said running average and ending operation of said iterative averager when noise level reaches a predetermined level,

an aligner for aligning at least some of substantially repetitive portions one with another,

a reference portion determiner, wherein said reference portion determiner comprising,

a first store for storing a first set of repetitive portions from said signal,

a second store for storing a second set of repetitive portions from said signal,

a second cross correlator for cross-correlating repetitive portions from said second set in turn with repetitive portions from said first set to produce a plurality of cross-correlation results for respective repetitive portions in said second set,

and a reference selector for selecting one of said repetitive portions in said second set as a reference portion in accordance with its respective cross-correlation results.

17. A device for noise reduction in a signal according to claim 16, wherein said reference selector comprises a threshold level comparator for comparing each cross-correlation result with a threshold and which is operable to select as said reference portion a repetitive portion having a highest number of respective cross-correlation results exceeding said threshold.

18. A device for noise reduction according to claim 16, wherein said reference selector comprises a summation unit for summing cross-correlation results of respective repetitive portions and which reference selector is operable to select as a reference portion a repetitive portion having the highest sum of respective cross-correlation results.

19. A device for noise reduction according to claim 16, wherein said reference selector comprises:

a threshold level comparator for comparing each cross-correlation result with a threshold, and

a summation unit for summing cross-correlation results of respective repetitive portions exceeding said threshold,

and which reference selector is operable to select as a reference portion a repetitive portion having a highest sum of respective cross-correlation results.