Frit material and bonding method for microfluidic separation devices
First Claim
Patent Images
1. A multi-layer separation device comprising:
- a first substantially planar adhesiveless polymeric device layer defining a separation channel;
a second substantially planar adhesiveless polymeric device layer defining an aperture;
a third substantially planar adhesiveless polymeric device layer defining an exit channel, wherein the second device layer is disposed between the first device layer and the third device layer; and
an adhesiveless polymeric frit disposed between the second device layer and the third device layer;
wherein the separation channel is in fluid communication with the exit channel by way of the aperture and the frit; and
wherein the second device layer and the third device layer are sufficiently bound around the frit to prevent substantially any lateral flow between the frit and the second device layer and between the frit and the third device layer at an operating pressure.
2 Assignments
0 Petitions
Accused Products
Abstract
A multi-layer microfluidic separation device comprises a polymeric membrane frit that may be securely bonded within the device and minimizes lateral wicking. Stationary phase material having an average particle size is retained by a frit having an average pore size that is smaller than the average particle size. In one embodiment, a secure bond is ensured by treating the polymer to match its surface energy to that of the materials to which it is bound. Treatments include plasma treatment, irradiation and the application of acids.
63 Citations
52 Claims
-
1. A multi-layer separation device comprising:
-
a first substantially planar adhesiveless polymeric device layer defining a separation channel; a second substantially planar adhesiveless polymeric device layer defining an aperture; a third substantially planar adhesiveless polymeric device layer defining an exit channel, wherein the second device layer is disposed between the first device layer and the third device layer; and an adhesiveless polymeric frit disposed between the second device layer and the third device layer; wherein the separation channel is in fluid communication with the exit channel by way of the aperture and the frit; and wherein the second device layer and the third device layer are sufficiently bound around the frit to prevent substantially any lateral flow between the frit and the second device layer and between the frit and the third device layer at an operating pressure. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
-
-
27. A multi-layer separation device comprising:
-
a first substantially planar adhesiveless polymeric device layer defining a plurality of separation channels; a second substantially planar adhesiveless polymeric device layer defining a plurality of apertures; a third substantially planar adhesiveless polymeric device layer defining a plurality of exit channels, wherein the second device layer is disposed between the first device layer and the third device layer; and an adhesiveless polymeric frit disposed between the second device layer and the third device layer; wherein each separation channel of the plurality of separation channels is in fluid communication with an exit channel of the plurality of exit channels by way of an aperture of the plurality of apertures and the frit; and wherein the second device layer and the third device layer are sufficiently bound around the frit to prevent substantially any lateral flow between the frit and the second device layer and between the frit and the third device layer at an operating pressure. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52)
-
Specification