Method of regulating glucose metabolism, and reagents related thereto

  • US 7,157,429 B1
  • Filed: 07/28/2000
  • Issued: 01/02/2007
  • Est. Priority Date: 02/02/1998
  • Status: Expired due to Term
First Claim
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1. A method for modifying glucose metabolism in a glucose intolerant animal, comprising administering to the animal, in a single daily oral dosage, a composition including one or more di-, tri- or tetra-peptidyl boronate or di-, tri- or tetra-peptidomimetic boronate protease inhibitors, wherein the boronate replaces the C-terminal carboxylate moiety, which inhibit DPIV-mediated proteolysis with a Ki of less than about 10 nM in an amount sufficient to modify glucose metabolism but not sufficient to suppress the immune system of the animal.

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