Compositions for the electronic detection of analytes utilizing monolayers
First Claim
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1. A composition comprising:
- a) an electrode comprising;
i) a monolayer comprising insulators; and
ii) a capture binding ligand wherein said capture binding ligand is covalently attached to said electrode via an attachment linker; and
,b) a target analyte binding ligand comprising at least one non-electrochemiluminescent electron transfer moiety (ETM) covalently attached to said target analyte binding ligand.
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Abstract
The present invention relates to the use of self-assembled monolayers with mixtures of conductive oligomers and insulators to detect target analytes.
411 Citations
20 Claims
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1. A composition comprising:
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a) an electrode comprising; i) a monolayer comprising insulators; and ii) a capture binding ligand wherein said capture binding ligand is covalently attached to said electrode via an attachment linker; and
,b) a target analyte binding ligand comprising at least one non-electrochemiluminescent electron transfer moiety (ETM) covalently attached to said target analyte binding ligand. - View Dependent Claims (2, 3, 4, 5, 6, 7, 15, 17, 18)
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8. A composition comprising:
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a) an electrode comprising; i) a monolayer comprising insulators; and ii) a capture binding ligand wherein said capture binding ligand is covalently attached to said electrode via an attachment linker; and
,b) a target analyte binding ligand comprising; i) nucleic acid; ii) at least one non-electrochemiluminescent electron transfer moiety (ETM) covalently attached to said target analyte binding ligand. - View Dependent Claims (9, 10, 11, 12, 13, 14, 16, 19, 20)
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Specification