Electrochemical detection method and device

  • US 7,169,289 B2
  • Filed: 02/10/2005
  • Issued: 01/30/2007
  • Est. Priority Date: 06/28/2002
  • Status: Expired due to Fees
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First Claim
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1. A device for the electrochemical detection of at least one type of a biochemical molecule contained in a liquid from a group of predetermined biochemical molecules of different types, comprising:

  • a means (1) for taking up the liquid, said means having at least one reference electrode (RE) and at least one counterelectrode (GE) and more than two working electrodes (AE1, AE2, AE3), with at least one working electrode (AE1, AE2, AE3) being provided for the detection of each type of a biochemical molecule, said working electrode being coated with a molecule that is complementary to the biochemical molecule to be detected, so that biochemical molecules of different types can be detected simultaneously,a current/voltage converter (S1, S2, S3) being connected downstream of each of the working electrodes (AE1, AE2, AE3) and having a first operational amplifier (OP1) and a first resistor (R1), the current/voltage converters (S1, S2, S3) holding all of the working electrodes (AE1, AE2, AE3) at the same potential,a means (AD) for measuring the currents flowing through the working electrodes (AE1, AE2, AE3), anda potentiostat (P) for generating a predetermined voltage profile which is variable during the measurement between the working electrodes (AE1, AE2, AE3) and the reference electrode (RE),said potentiostat (P) comprising a second operational amplifier (OP2) and a second resistor (R2), and a third operational amplifier (OP3) and a third resistor (R3),with the third operational amplifier (OP3), to whose output the counterelectrode (GE) is connected and whose inverting input (0P3

    ) is connected via the second resistor (R2) to the output of the second operational amplifier (OP2), being connected via the third resistor (R3) to a device for generating a selectable desired voltage, with the noninverting input (0P3+) of the third operational amplifier (OP3) being grounded.

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