Device for determining a glucose concentration in a tissue fluid
First Claim
1. A device for determining a glucose concentration in a tissue fluid, the device comprisinga microdialysis probe for a diffusion exchange of glucose with surrounding tissue fluid,a perfusion device for perfusing the microdialysis probe with glucose-containing perfusate to obtain dialysate,a dialysate glucose content measuring cell located downstream of the microdialysis probe, anda control device, which adjusts the content of glucose in the perfusate upstream of the microdialysis probe to the glucose content of the tissue fluid in accordance with a command variable derived from measurement signals of the measuring cell.
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Abstract
The invention concerns an arrangement for determining the concentration of glucose in a tissue fluid. In the microdialysis technology used for this purpose, perfusate-containing glucose is transported in intermittent delivery pulses through a microdialysis probe inserted into the tissue fluid and dialysate obtained in this process is passed to a measuring cell to record the glucose content. In order to achieve an exact determination of glucose even with a reduced dialysis period, it is proposed that the starting content of glucose in the perfusate is adapted to the glucose content of the tissue fluid by means of a control device in accordance with a command variable derived from the measurement signals of the measuring cell. When the control deviation is negligible the momentary starting content of glucose in the perfusate can be determined as a measure for the glucose content of the tissue fluid.
164 Citations
26 Claims
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1. A device for determining a glucose concentration in a tissue fluid, the device comprising
a microdialysis probe for a diffusion exchange of glucose with surrounding tissue fluid, a perfusion device for perfusing the microdialysis probe with glucose-containing perfusate to obtain dialysate, a dialysate glucose content measuring cell located downstream of the microdialysis probe, and a control device, which adjusts the content of glucose in the perfusate upstream of the microdialysis probe to the glucose content of the tissue fluid in accordance with a command variable derived from measurement signals of the measuring cell.
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17. A device for determining a glucose concentration in a tissue fluid, comprising
a microdialysis probe inserted into the tissue fluid, at least two reservoirs for holding perfusion liquids with different glucose concentrations, a transport unit to perfuse the microdialysis probe with glucose-containing perfusate to obtain dialysate, a flow-through measuring cell located downstream of the microdialysis probe to register measurement signals that correlate with the glucose content of the dialysate, and a control device connected on an input side to the measuring cell, which control device has a flow mixer connected on an inlet side to the reservoirs and on an outlet side to the microdialysis probe, which acts as an adjuster to regulate the content of glucose in the perfusate upstream of the microdialysis probe.
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18. A device for determining the glucose concentration in a tissue fluid, comprising
a microdialysis probe, a perfusion device in communication with the micro dialysis probe to perfuse the microdialysis probe with glucose-containing perfusate to obtain dialysate, a measuring cell being located downstream of the microdialysis probe, and having an electrode sensor formed to detect measurement signals that correlate with the glucose content of the dialysate, and a control device, which adjusts the content of glucose in the perfusate upstream of the microdialysis probe to the glucose content of the tissue fluid in accordance with a command variable corresponding with the glucose concentration of the tissue fluid and being derived from the measurement signals of measuring cell.
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26. A device for determining a glucose concentration in a tissue fluid, comprising
a microdialysis probe inserted into the tissue fluid, at least two reservoirs for holding perfusion liquids with different glucose concentrations, a transport unit in communication with the microdialysis probe and the at least two reservoirs, to perfuse the microdialysis probe with glucose-containing perfusate to obtain dialysate, a flow-through measuring cell located downstream of the microdialysis probe and formed to register measurement signals that correlate with the glucose content of the dialysate, and a control device in communication wit the measuring cell, the control device having a flow mixer in communication with at least two reservoirs and with the microdialysis probe to act as an adjuster to regulate the content of glucose in the perfusate upstream of the microdialysis probe.
Specification