Compositions and methods for transdermal oxybutynin therapy

  • US 7,179,483 B2
  • Filed: 08/06/2004
  • Issued: 02/20/2007
  • Est. Priority Date: 04/26/2000
  • Status: Expired due to Term
First Claim
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1. A method of treating with oxybutynin a subject having overactive bladder, while minimizing an anticholinergic or antimuscarinic adverse drug experience associated with said oxybutynin treatment therapy comprising the step of:

  • administering a transdermal formulation comprising oxybutynin to a subject to provide a plasma area under the curve (AUC) ratio of oxybutynin to an oxybutynin metabolite of from about 0.5;

    1 to about 5;

    1, wherein the transdermal formulation optionally includes a permeation enhancer, and wherein the transdermal formulation is in the form of;

    (a) topical formulation selected from the group consisting of ointments, lotions, gels, pastes, mousses, aerosols and skin creams, or (b) transdermal patches selected from the group consisting of adhesive matrix patches and liquid reservoir systems.

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