Method and system for nerve stimulation prior to and during a medical procedure

• US 7,184,829 B2
• Filed: 01/30/2004
• Issued: 02/27/2007
• Est. Priority Date: 04/30/1996
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Keogh, James R., Jahns, Scott E., Hill, Michael R. S.
• Primary Examiner(s): LAYNO, CARL HERNANDZ
• Application Number:
  US10/768,999
• Publication Number:
  US 20040186517A1
• Time in Patent Office: 1,124 Days
• Field of Search: 607 2- 3, 607 9- 10, 128897-898
• US Class Current: 607/2
• CPC Class Codes: A61N 1/056 Transvascular endocardial electrode systems
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/362 Heart stimulators heart defibrillators A61N1/39
• CPC Class Codes: A61N 1/3629 in combination with non-electric therapy
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585
• CPC Class Codes: A61N 1/37288 Communication to several implantable medical devices within one patient
• CPC Class Codes: A61N 1/385 Devices for inducing an abnormal cardiac function, e.g. fibrillation
• CPC Class Codes: A61N 1/39 Heart defibrillators

Abstract

A method of performing a medical procedure, such as surgery, is provided. A nerve is stimulated in order to adjust the beating of the heart to a first condition, such as a stopped or slowed condition. The medical procedure is performed on the heart or another organ. The stimulation of the nerve is stopped in order to adjust the beating of the heart to a second condition, such as a beating condition. The heart itself may also be stimulated to a beating condition, such as by pacing. The stimulation of the nerve may be continued in order to allow the medical procedure to be continued. Systems and devices for performing the medical procedure are also provided.

Claims

1. A method for controllably stopping or slowing a heart intermittently during a medical procedure, comprising:

providing a controllable nerve stimulator capable of automatically stopping stimulation of a vagal nerve, the nerve stimulator comprising a nerve stimulation electrode;

positioning the nerve stimulation electrode in a position suitable for stimulating a vagal nerve to stop or slow the heart;

controllably starting stimulation of the vagal nerve;

automatically stopping stimulation of the vagal nerve;

continuing to start and stop stimulation of the vagal nerve in order to stop or slow the heart intermittently during the medical procedure.

2. The method of claim 1 wherein the vagal nerve is stimulated using transvascular stimulation.

3. The method of claim 1 wherein the vagal nerve is stimulated using endotracheal stimulation.

4. The method of claim 1 wherein the vagal nerve is stimulated using esophageal stimulation.

5. The method of claim 1 wherein the vagal nerve is stimulated using transcutaneous stimulation.

6. The method of claim 1 wherein the vagal nerve is stimulated using intracutaneous stimulation.

7. The method of claim 1 further comprising delivering at least one drug during the medical procedure.

8. The method of claim 7 wherein the drug is selected from the group consisting of:

a beta-blocker, a cholinergic agent, a cholinesterase inhibitor, a calcium channel blocker, a sodium channel blocker, a potassium channel agent, adenosine, an adenosine receptor agonist, an adenosine deaminase inhibitor, dipyridamole, a monoamine oxidase inhibitor, digoxin, digitalis, lignocaine, a bradykinin agent, a serotoninergic agonist, an antiarrythmic agent, a cardiac glycoside a local anesthetic, atropine, a calcium solution, an agent that promotes heart rate, an agent that promotes heart contractions, dopamine, a catecholamine, an inotrope glucagon, a hormone, forskolin, epinephrine, norepinephrine, thyroid hormone, a phosphodiesterase inhibitor, prostacyclin, prostaglandin and a methylxanthine.

9. The method of claim 7 wherein the drug is naturally occurring.

10. The method of claim 7 wherein the drug is chemically synthesized.

11. The method of claim 1 further comprising stimulating the heart.

12. The method of claim 11 wherein stimulation of the vagal nerve occurs in an inverse relationship to stimulation of the heart.

13. The method of claim 11 wherein the heart is stimulated by pacing.

14. The method of claim 1 wherein the medical procedure is selected from the group consisting of:

surgical procedures, non-surgical procedures, endoscopic procedures, fluoroscopic procedures, stent delivery procedures, aortic aneurysm repairs, cranial aneurysm repairs, delivery of drugs, delivery of biological agents, cardiac surgery with cardiopulmonary bypass circuits, cardiac surgery without cardiopulmonary bypass circuits, brain surgery, cardiograms, heart valve repair, heart valve replacement, MAZE procedures, transmyocardial revascularization, CABG procedures, beating heart surgery, vascular surgery, neurosurgery, electrophysiology procedures, diagnostic ablation of arrhythmias, therapeutic ablation of arrhythmias, endovascular procedures, treatment of injuries to the liver, treatment of the spleen, treatment of the heart, treatment of the lungs, treatment of major blood vessels, non-invasive procedures, invasive procedures, and port-access procedures.

15. A method of performing a medical procedure, comprising:

providing a nerve stimulator capable of automatically stopping stimulation of a vagal nerve;

stimulating the vagal nerve to reduce heart rate;

automatically stopping stimulation of the vagal nerve; and

stimulating the vagal nerve a subsequent time in order to reduce heart rate a subsequent time.

16. The method of claim 15 wherein the vagal nerve is stimulated using transvascular stimulation.

17. The method of claim 15 wherein the vagal nerve is stimulated using endotracheal stimulation.

18. The method of claim 15 wherein the vagal nerve is stimulated using esophageal stimulation.

19. The method of claim 15 wherein the vagal nerve is stimulated using transcutaneous stimulation.

20. The method of claim 15 wherein the vagal nerve is stimulated using intracutaneous stimulation.

21. The method of claim 15 further comprising delivering at least one drug during the medical procedure.

22. The method of claim 21 wherein the drug is selected from the group consisting of:

a beta-blocker, a cholinergic agent, a cholinesterase inhibitor, a calcium channel blocker, a sodium channel blocker, a potassium channel agent, adenosine, an adenosine receptor agonist, an adenosine deaminase inhibitor, dipyridamole, a monoamine oxidase inhibitor, digoxin, digitalis, lignocaine, a bradykinin agent, a serotoninergic agonist, an antiarrythmic agent, a cardiac glycoside a local anesthetic, atropine, a calcium solution, an agent that promotes heart rate, an agent that promotes heart contractions, dopamine, a catecholamine, an inotrope glucagon, a hormone, forskolin, epinephrine, norepinephrine, thyroid hormone, a phosphodiesterase inhibitor, prostacyclin, prostaglandin and a methylxanthine.

23. The method of claim 21 wherein the drug is naturally occurring.

24. The method of claim 21 wherein the drug is chemically synthesized.

25. The method of claim 15 further comprising stimulating the heart.

26. The method of claim 25 wherein stimulation of the vagal nerve occurs in an inverse relationship to stimulation of the heart.

27. The method of claim 25 wherein the heart is stimulated by pacing.

28. The method of claim 25 wherein the medical procedure is selected from the group consisting of:

surgical procedures, non-surgical procedures, endoscopic procedures, fluoroscopic procedures, stent delivery procedures, aortic aneurysm repairs, cranial aneurysm repairs, delivery of drugs, delivery of biological agents, cardiac surgery with cardiopulmonary bypass circuits, cardiac surgery without cardiopulmonary bypass circuits, brain surgery, cardiograms, heart valve repair, heart valve replacement, MAZE procedures, transmyocardial revascularization, CABG procedures, beating heart surgery, vascular surgery, neurosurgery, electrophysiology procedures, diagnostic ablation of arrhythmias, therapeutic ablation of arrhythmias, endovascular procedures, treatment of injuries to the liver, treatment of the spleen, treatment of the heart, treatment of the lungs, treatment of major blood vessels, non-invasive procedures, invasive procedures, and port-access procedures.

29. A method of electrically manipulating heart rhythm during therapeutic treatment of a heart, comprising:

providing a nerve stimulator, the nerve stimulator comprising a nerve stimulation electrode;

positioning the nerve stimulation electrode in a position suitable for electrically stimulating a vagal nerve to manipulate heart rhythm; and

intermittently starting and automatically stopping electrical stimulation of the vagal nerve subsequent times in order to manipulate heart rhythm during therapeutic treatment of the heart.

30. The method of claim 29 wherein the nerve stimulation electrode is positioned in a transvascular position.

31. The method of claim 29 wherein the nerve stimulation electrode is positioned in a transcutaneous position.

32. The method of claim 29 wherein the nerve stimulation electrode is positioned in an intracutaneous position.

33. The method of claim 29 further comprising delivering at least one drug during treatment of the heart.

34. The method of claim 33 wherein the drug is chemically synthesized.

35. The method of claim 29 further comprising stimulating the heart.

36. The method of claim 35 wherein stimulation of the vagal nerve occurs in an inverse relationship to stimulation of the heart.

37. The method of claim 35 wherein the heart is stimulated by pacing.

38. A method of electrically manipulating heart rhythm during therapeutic treatment of a heart, comprising:

providing a nerve stimulator, the nerve stimulator comprising a nerve stimulation electrode;

positioning the nerve stimulation electrode in a position suitable for electrically stimulating a vagal nerve to manipulate heart rhythm; and

intermittently starting and stopping electrical stimulation of the vagal nerve subsequent times in order to manipulate heart rhythm during therapeutic treatment of the heart;

the nerve stimulation electrode being positioned in an endotracheal position.

39. A method of electrically manipulating heart rhythm during therapeutic treatment of a heart, comprising:

providing a nerve stimulator, the nerve stimulator comprising a nerve stimulation electrode;

positioning the nerve stimulation electrode in a position suitable for electrically stimulating a vagal nerve to manipulate heart rhythm; and

intermittently starting and stopping electrical stimulation of the vagal nerve subsequent times in order to manipulate heart rhythm during therapeutic treatment of the heart;

the nerve stimulation electrode being positioned in an esophageal position.

40. A method of electrically manipulating heart rhythm during therapeutic treatment of a heart, comprising:

providing a nerve stimulator, the nerve stimulator comprising a nerve stimulation electrode;

positioning the nerve stimulation electrode in a position suitable for electrically stimulating a vagal nerve to manipulate heart rhythm;

intermittently starting and stopping electrical stimulation of the vagal nerve subsequent times in order to manipulate heart rhythm during therapeutic treatment of the heart; and

delivering at least one drug during treatment of the heart;

the drug being selected from the group consisting of;

a beta-blocker, a cholinergic agent, a cholinesterase inhibitor, a calcium channel blocker, a sodium channel blocker, a potassium channel agent, adenosine, an adenosine receptor agonist, an adenosine deaminase inhibitor, dipyridamole, a monoamine oxidase inhibitor, digoxin, digitalis, lignocaine, a bradykinin agent, a serotoninergic agonist, an antiarrythmic agent, a cardiac glycoside a local anesthetic, atropine, a calcium solution, an agent that promotes heart rate, an agent that promotes heart contractions, dopamine, a catecholamine, an inotrope glucagon, a hormone, forskolin, epinephrine, norepinephrine, thyroid hormone, a phosphodiesterase inhibitor, prostacyclin, prostaglandin and a methylxanthine.

41. A method of electrically manipulating heart rhythm during therapeutic treatment of a heart, comprising:

providing a nerve stimulator, the nerve stimulator comprising a nerve stimulation electrode;

positioning the nerve stimulation electrode in a position suitable for electrically stimulating a vagal nerve to manipulate heart rhythm;

intermittently starting and stopping electrical stimulation of the vagal nerve subsequent times in order to manipulate heart rhythm during therapeutic treatment of the heart; and

delivering at least one drug during treatment of the heart;

the drug being naturally occurring.

42. A method of electrically manipulating cardiac rhythm during a medical procedure, comprising:

providing a nerve stimulator, the nerve stimulator comprising a stimulation electrode;

positioning the stimulation electrode in a position suitable for stimulating a carotid sinus nerve to manipulate cardiac rhythm;

intermittently starting and stopping stimulation of the carotid sinus nerve multiple times in order to manipulate cardiac rhythm during a medical procedure.

43. A method of electrically manipulating cardiac rhythm during a medical procedure, comprising:

providing a stimulator, the stimulator comprising a stimulation electrode;

positioning the stimulation electrode in a position suitable for stimulating Purkinje fibers to stop or slow cardiac rhythm;

intermittently starting and stopping stimulation of the Purkinje fibers multiple times in order to manipulate cardiac rhythm during a medical procedure.

44. A method of electrically manipulating cardiac rhythm during a medical procedure, comprising:

providing a stimulator, the stimulator comprising a stimulation electrode;

positioning the stimulation electrode in a position suitable for stimulating a junction of an AV node and a His bundle to manipulate cardiac rhythm;

intermittently starting and stopping stimulation of the junction of the AV node and the His bundle multiple times in order to manipulate cardiac rhythm during a medical procedure.

45. A method of electrically manipulating cardiac rhythm during a medical procedure, comprising:

providing a stimulator, the stimulator comprising a stimulation electrode;

positioning the stimulation electrode in a position suitable for stimulating a fat pad associated with AV node to manipulate cardiac rhythm; and

intermittently starting and stopping stimulation of the fat pad associated with the AV node multiple times in order to manipulate cardiac rhythm during a medical procedure.

46. A method of electrically manipulating cardiac rhythm during a medical procedure, comprising:

providing a stimulator, the stimulator comprising a stimulation electrode;

positioning the stimulation electrode in a position suitable for stimulating a fat pad associated with a SA node to manipulate cardiac rhythm; and

intermittently starting and stopping stimulation of the fat pad associated with the SA node multiple times in order to manipulate cardiac rhythm during a medical procedure.