Implantable and sealable system for unidirectional delivery of therapeutic agents to tissues
First Claim
1. An implantable delivery device for delivery of at least a first therapeutic agent into a target tissue, comprising:
- a housing, said housing comprising a reservoir with a release port for release of at least a first therapeutic agent into a target tissue, said reservoir having at least a first wall that is substantially impermeable to a first therapeutic agent to be placed therein,a sealing base for sealing said release port to a target tissue, wherein when said release port is sealed to a target tissue a first therapeutic agent in said reservoir is substantially prohibited from release by said device other than through said release port into the target tissue, andan attachment mechanism to facilitate sealing of said release port to a target tissue, said attachment mechanism comprising at least one member of the group consisting of a sufficient amount of an adhesive for adhering said sealing base to a target tissue wherein said adhesive is held within at least one cavity or channel within said sealing base, and at least one stabilizer on said first wall for engaging a buckling band or suture for sealably engaging said device with a target tissue.
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Accused Products
Abstract
A surgically implantable and sealable delivery device that upon contact of its contents via an interface window or port therein with an organ or tissue exposes a therapeutic agent to the organ or tissue surface, allowing a controlled, selective and unidirectional diffusion of the agent into the tissue or organ. The device protects adjacent organs or tissue structures from unnecessary high levels of the delivered agent. Novel methods to deliver chemotherapeutics or bioactive agents to mammalian organs or tissues through a surgically implanted device by the way of a selective and protected diffusion mechanism are disclosed as well as method to achieve the sealing properties of the device.
260 Citations
72 Claims
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1. An implantable delivery device for delivery of at least a first therapeutic agent into a target tissue, comprising:
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a housing, said housing comprising a reservoir with a release port for release of at least a first therapeutic agent into a target tissue, said reservoir having at least a first wall that is substantially impermeable to a first therapeutic agent to be placed therein, a sealing base for sealing said release port to a target tissue, wherein when said release port is sealed to a target tissue a first therapeutic agent in said reservoir is substantially prohibited from release by said device other than through said release port into the target tissue, and an attachment mechanism to facilitate sealing of said release port to a target tissue, said attachment mechanism comprising at least one member of the group consisting of a sufficient amount of an adhesive for adhering said sealing base to a target tissue wherein said adhesive is held within at least one cavity or channel within said sealing base, and at least one stabilizer on said first wall for engaging a buckling band or suture for sealably engaging said device with a target tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65)
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66. An implantable delivery device for delivery of at least a first therapeutic agent into a target tissue, comprising:
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a housing, said housing comprising a reservoir with a release part for release of at least a first therapeutic agent into a target tissue, said reservoir having at least a first wall that is substantially impermeable to a first therapeutic agent to be placed therein, a sealing base for sealing said release port to a target tissue, wherein when said release port is sealed to a target tissue a first therapeutic agent in said reservoir is substantially prohibited from release by said device other than through said release port into the target tissue, and an attachment mechanism to facilitate sealing of said release port to a target tissue, wherein said attachment mechanism comprises a sufficient amount of an adhesive for adhering said sealing base to a target tissue, wherein said adhesive is held within at least one cavity or channel within said sealing base. - View Dependent Claims (67, 68, 69)
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70. An implantable delivery device for delivery of at least a first therapeutic agent into a target tissue, comprising:
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a housing, said housing comprising a reservoir with a release port for release of at least a first therapeutic agent into a target tissue, said reservoir having at least a first wall, a sealing base for sealing said release port to a target tissue, wherein when said release port is sealed to a target tissue a first therapeutic agent in said reservoir can be released through said release port into the target tissue, and an attachment mechanism to facilitate sealing of said release port to a target tissue, wherein said attachment mechanism comprises a suture holder for engaging at least one suture operatively attached to tissue surrounding a target tissue, and wherein said first wall is impermeable to a first therapeutic agent placed in said reservoir, wherein said release port has a perimeter, and said suture holder comprises at least one groove in said first wall, wherein said at least one groove can be engaged by at least one suture or buckling band to fix said device to a target tissue so that said release port is sealed to the tissue.
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71. An implantable delivery device for delivery of at least a first therapeutic agent into a target tissue, comprising:
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a housing, said housing comprising a reservoir with a release port for release of at least a first therapeutic agent into a target tissue, said reservoir having at least a first wall, a sealing base for sealing said release port to a target tissue, wherein when said release port is sealed to a target tissue a first therapeutic agent in said reservoir can be released through said release port into the target tissue, and an attachment mechanism to facilitate sealing of said release port to a target tissue, wherein said device further comprises a refill port, wherein said refill port comprises a material selected from the group consisting of a dye, a radiosensitive marker, and an echogenic marker so that said refill port is indicated by said material.
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72. An implantable delivery device for delivery of at least a first therapeutic agent into a target tissue, comprising:
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a housing, said housing comprising a reservoir with a release port for release of at least a first therapeutic agent into a target tissue, said reservoir having at least a first wall that is substantially impermeable to a first therapeutic agent to be placed therein, a sealing base for sealing said release port to a target tissue, wherein when said release port is sealed to a target tissue a first therapeutic agent in said reservoir is substantially prohibited from release by said device other than through said release port into the target tissue, and an attachment mechanism to facilitate sealing of said release port to a target tissue, said attachment mechanism comprising at least one member of the group consisting of a sufficient amount of an adhesive for adhering said sealing base to a target tissue wherein said adhesive is held within at least one cavity or channel within said sealing base, and at least one stabilizer on said first wall for engaging a buckling band or suture for sealably engaging said device with a target tissue, wherein said sealing base has a greater curvature than the targeted tissue surface.
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Specification