Apparatus and method for delivering therapeutic and diagnostic agents
First Claim
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1. A method for delivering a selected diagnostic or therapeutic agent to a target site within a selected body tissue having a surface, comprising the steps of:
- (a) providing a drug-delivery tool comprising(i) an accessing device having distal and proximal ends, an inner lumen extending therebetween, a drug-delivery reservoir, and a user-control structure;
(ii) a tissue-penetrating implement carried on the distal end of the accessing device for axial movement in and out of the lumen, wherein the implement comprises a tip for penetrating the body tissue, and is operatively connected to the user-control structure; and
(iii) at least a first transducer located at the distal end of the accessing device;
(b) placing the distal end of the accessing device into contact with a selected body tissue surface;
(c) manipulating the orientation of the accessing device to a desired orientation, based on at least one signal from the first transducer;
(d) applying pressure to the selected body tissue surface with the distal end of the accessing device to create a seal;
(e) selectively actuating the tissue-penetrating implement to penetrate the selected body tissue surface; and
(f) delivering a drug while maintaining the seal.
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Abstract
A drug-delivery tool and method for delivering a diagnostic or therapeutic agent to a target site within a selected body tissue, such as the myocardium of the heart, is disclosed. The drug-delivery tool generally includes an accessing device having a tissue-penetrating implement in its distal-end region, and elements for delivering a selected agent into a cavity formed by the implement. Methods of use are also described.
125 Citations
17 Claims
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1. A method for delivering a selected diagnostic or therapeutic agent to a target site within a selected body tissue having a surface, comprising the steps of:
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(a) providing a drug-delivery tool comprising (i) an accessing device having distal and proximal ends, an inner lumen extending therebetween, a drug-delivery reservoir, and a user-control structure; (ii) a tissue-penetrating implement carried on the distal end of the accessing device for axial movement in and out of the lumen, wherein the implement comprises a tip for penetrating the body tissue, and is operatively connected to the user-control structure; and (iii) at least a first transducer located at the distal end of the accessing device; (b) placing the distal end of the accessing device into contact with a selected body tissue surface; (c) manipulating the orientation of the accessing device to a desired orientation, based on at least one signal from the first transducer; (d) applying pressure to the selected body tissue surface with the distal end of the accessing device to create a seal; (e) selectively actuating the tissue-penetrating implement to penetrate the selected body tissue surface; and (f) delivering a drug while maintaining the seal. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method for delivering a selected diagnostic or therapeutic agent to a target site within a selected body tissue having a surface, comprising the steps of:
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(a) providing a drug-delivery tool comprising (i) an accessing device having distal and proximal ends, an inner lumen extending therebetween, a drug-delivery reservoir, and a user-control structure; (ii) a tissue-penetrating implement carried on the distal end of the accessing device and operatively connected to the user-control structure; and (iii) at least a first transducer located at the distal end of the accessing device; (b) placing the distal end of the accessing device into contact with a selected body tissue surface; (c) manipulating the orientation of the accessing device to a desired orientation, based on at least one signal from the first transducer; (d) applying pressure to the selected body tissue surface with the distal end of the accessing device to create a seal when the body tissue is in a diastolic state; and (e) maintaining the seal while the body tissue is in a systolic state. - View Dependent Claims (15, 16, 17)
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Specification