Dynamic device therapy control for treating post myocardial infarction patients

• US 7,215,997 B2
• Filed: 12/22/2003
• Issued: 05/08/2007
• Est. Priority Date: 12/22/2003
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Pastore, Joseph M., Yu, Yinghong, Ding, Jiang
• Primary Examiner(s): LAYNO, CARL HERNANDZ
• Application Number:
  US10/744,900
• Publication Number:
  US 20050137631A1
• Time in Patent Office: 1,233 Days
• Field of Search: None
• US Class Current: 607/18
• CPC Class Codes: A61N 1/365 controlled by a physiological parameter, e.g. heart potential evoked response A61N1/371

Abstract

A cardiac rhythm management system includes an implantable device executing a dynamic pacing algorithm after an myocardial infarction (MI) event. The dynamic pacing algorithm dynamically adjusts one or more pacing parameters based on a person'"'"'s gross physical activity level. Examples of the one or more pacing parameters include atrioventricular pacing delays and pacing channels/sites. The dynamic pacing algorithm provides for improved hemodynamic performance when a person'"'"'s metabolic need is high, and post MI remodeling control when the person'"'"'s metabolic need is low.

Claims

1. An implantable pacemaker comprising:

a sensing circuit to sense at least one electrogram;

a pacing circuit to deliver pacing pulses;

an activity sensor to sense an activity level; and

a pacing controller coupled to the sensing circuit, the pacing circuit, and the activity sensor, the pacing controller including;

a dynamic pacing parameter controller adapted to be activated by an activation signal and adapted to dynamically adjust one or more pacing parameters based on at least the activity level after being activated;

a myocardial infarction detector to detect a signal indicative of a myocardial infarction event; and

a pacing algorithm selector adapted to generate the activation signal after the signal indicative of the myocardial infarction event is detected.

2. The implantable pacemaker of claim 1, wherein the activity sensor comprises a heart rate monitor to detect a heart rate indicative of the activity level.

3. The implantable pacemaker of claim 1, wherein the activity sensor comprises an accelerometer to sense an acceleration indicative of the activity level.

4. The implantable pacemaker of claim 1, wherein the activity sensor comprises a minute ventilation sensor to sense a signal indicative of a minute ventilation.

5. The implantable pacemaker of claim 4, wherein the minute ventilation sensor comprises an impedance sensor.

6. The implantable pacemaker of claim 1, wherein the dynamic pacing parameter controller comprises an atrioventricular (AV) delay adjuster adapted to dynamically adjusting at least one AV delay based on at least the activity level.

7. The implantable pacemaker of claim 6, wherein the AV delay adjuster comprises an AV delay selector to dynamically select a value for the at least one AV delay from a plurality of predetermined AV delay values based on at least the activity level.

8. The implantable pacemaker of claim 6, wherein the dynamic pacing parameter controller further comprises an interventricular delay adjuster adapted to dynamically adjusting at least one interventicular delay based on at least the activity level.

9. The implantable pacemaker of claim 8, wherein the interventricular delay adjuster comprises an interventricular delay selector to dynamically select a value for the at least one interventricular delay from a plurality of predetermined interventricular delay values based on at least the activity level.

10. The implantable pacemaker of claim 6, wherein the pacing circuit comprises a plurality of pacing channels to deliver the pacing pulses to a plurality of cardiac sites, and the dynamic pacing parameter controller comprises a pacing channel selector adapted to dynamically select a predetermined set of one or more pacing channels from the plurality of pacing channels based on at least the activity level.

11. The implantable pacemaker of claim 10, further comprising an activity level comparator to compare the activity level to one or more predetermined activity level thresholds, wherein the dynamic pacing parameter controller is adapted to control one or more pacing parameters based on at least the result of the comparison.

12. The implantable pacemaker of claim 11, wherein the pacing algorithm selector comprises a timer to time a predetermined period starting when the signal indicative of the myocardial infarction event is detected and activate the dynamic pacing parameter controller after the predetermined period expires.

13. The implantable pacemaker of claim 1, wherein the myocardial infarction detector comprises a command receiver to receive an external activation command issued in response to the myocardial infarction event, the external activation command being the signal indicative of the myocardial infarction event.

14. The implantable pacemaker of claim 13, wherein the dynamic pacing parameter controller further comprises a parameter receiver to receive values for the one or more pacing parameters.

15. The implantable pacemaker of claim 1, wherein the myocardial infarction detector comprises an ischemia detector.

16. The implantable pacemaker of claim 15, wherein the ischemia detector comprises an electrogram-based ischemia detector.

17. The implantable pacemaker of claim 15, wherein the ischemia detector comprises an impedance sensor.

18. The implantable pacemaker of claim 15, wherein the ischemia detector comprises an accelerometer sensing cardiac wall motion.

19. The implantable pacemaker of claim 1, further comprising a hemodynamic performance sensor to sense a signal indicative of hemodynamic performance.

20. The implantable pacemaker of claim 19, wherein the pacing controller comprises a signal analyzer to receive the signal indicative of hemodynamic performance, and the pacing algorithm selector determines whether to activate or deactivate the dynamic pacing parameter controller based on the signal indicative of hemodynamic performance.

21. The implantable pacemaker of claim 20, wherein the hemodynamic performance sensor comprises an impedance sensor sensing a signal indicative of minute ventilation.

22. The implantable pacemaker of claim 20, wherein the hemodynamic performance sensor comprises an acoustic sensor to sense heart sounds and a heart sound analyzer to detect first heart sounds (S1) and measure an S1 duration.

23. The implantable pacemaker of claim 20, wherein the hemodynamic performance sensor comprises a pressure sensor to sense a signal indicative of a left ventricular pressure and a pressure analyzer to calculate an maximum positive derivative of the left ventricular pressure, LV+dp/dt.

24. The implantable pacemaker of claim 20, wherein the hemodynamic performance sensor comprises a stroke volume sensor to sense a signal indicative of stroke volume.

25. A cardiac rhythm management system, comprising:

an implantable medical device including;

a sensing circuit to sense at least one electrogram;

a pacing circuit to deliver pacing pulses;

an activity sensor to sense an activity level; and

a pacing controller coupled to the sensing circuit, the pacing circuit, and the activity sensor, the pacing controller including;

a dynamic pacing parameter controller adapted to be activated by an activation signal and adapted to dynamically adjust one or more pacing parameters based on at least the activity level after being activated;

a myocardial infarction detector to detect a signal indicative of a myocardial infarction event; and

a pacing algorithm selector adapted to generate the activation signal after the signal indicative of the myocardial infarction event is detected; and

an external system communicatively coupled to the implantable medical device via telemetry, the external system including a user input to receive commands controlling operations of the implanted medical device.

26. The cardiac rhythm management system of claim 25, wherein the myocardial infarction detector comprises a command receiver to receive an external activation command as the signal indicative of the myocardial infarction event, and the user input is adapted to receive a user activation command and issue the external activation command in response to the user activation command.

27. The cardiac rhythm management system of claim 26, wherein the user input comprises an on/off selector allowing an entry of the user activation command by an on-selection.

28. The cardiac rhythm management system of claim 26, wherein the dynamic pacing parameter controller further comprises a parameter receiver to receive values for the one or more pacing parameters, and the user input comprises parameter entry fields to receive one or more values for the one or more pacing parameters.

29. The cardiac rhythm management system of claim 26, wherein the implantable medical device further comprises a hemodynamic performance sensor to sense a signal indicative of hemodynamic performance.

30. The cardiac rhythm management system of claim 29, wherein the hemodynamic performance sensor comprises the activity sensor.

31. The cardiac rhythm management system of claim 29, wherein the external system comprises a signal receiver to receive one or more of the at least one electrogram, the activity level, and the signal indicative of hemodynamic performance.

32. The cardiac rhythm management system of claim 31, wherein the external system comprises a presentation device to present the received one or more of the at least one electrogram, the signal indicative of hemodynamic performance.

33. The cardiac rhythm management system of claim 31, wherein the external system comprises an external controller to issue the external activation command based on the received one or more of the at least one electrogram, the signal indicative of a measure of hemodynamic performance.

34. The cardiac rhythm management system of claim 31, wherein the external system comprises a programmer.

35. The cardiac rhythm management system of claim 31, wherein the external system comprises:

an external device coupled to the implantable medical device via telemetry;

a network coupled to the external device; and

a remote device coupled to the network.

36. The cardiac rhythm management system of claim 35, wherein the remote device comprises a presentation device and the user input.

37. A method for operating an implantable pacemaker, comprising:

detecting a signal indicative of a myocardial infarction event; and

executing a dynamic pacing algorithm after the signal indicative of the myocardial infarction event is detected, the executing including;

sensing an activity level;

dynamically adjusting one or more pacing parameters based on at least the activity level;

sensing at least one electrogram; and

delivering pacing pulses.

38. The method of claim 37, wherein sensing the activity level comprises detecting heart rate.

39. The method of claim 37, wherein sensing the activity level comprises sensing an acceleration signal.

40. The method of claim 37, wherein sensing the activity level comprises sensing a signal indicative of a minute ventilation.

41. The method of claim 37, wherein dynamically adjusting the one or more pacing parameters comprises dynamically adjusting at least one AV delay based on at least the activity level.

42. The method of claim 41, wherein dynamically adjusting the at least one AV delay comprises dynamically selecting a value for the at least one AV delay from a plurality of predetermined AV delay values based on at least the activity level.

43. The method of claim 41, wherein dynamically adjusting the one or more pacing parameters further comprises dynamically adjusting at least one interventricular delay based on at least the activity level.

44. The method of claim 43, wherein dynamically adjusting the at least one interventricular delay comprises dynamically selecting a value for the at least one interventricular delay from a plurality of predetermined interventricular delay values based on at least the activity level.

45. The method of claim 41, wherein dynamically adjusting the one or more pacing parameters further comprises dynamically selecting one or more pacing channels from a plurality of predetermined pacing channels based on at least the activity level.

46. The method of claim 37, wherein dynamically adjusting the one or more pacing parameters comprises comparing the activity level to one or more predetermined threshold levels and adjusting the one or more pacing parameters based on at least the result of the comparison.

47. The method of claim 37, wherein executing the dynamic pacing algorithm comprises:

timing a predetermined time period starting when the signal indicative of the myocardial infarction event is detected; and

starting to execute the dynamic pacing algorithm upon an expiration of the predetermined time period.

48. The method of claim 37, wherein detecting the signal indicative of the myocardial infarction event comprises receiving an external activation command from an external system communicating to the implantable pacemaker, the external activation command being the signal indicative of the myocardial infarction event.

49. The method of claim 48, further comprising receiving values for the one or more pacing parameters from the external system.

50. The method of claim 37, wherein detecting the signal indicative of the myocardial infarction event comprises detecting an ischemia.

51. The method of claim 50, wherein detecting the ischemia comprises detecting the ischemia from the at least one electrogram.

52. The method of claim 50, wherein detecting the ischemia comprises sensing an impendance.

53. The method of claim 50, wherein detecting the ischemia comprises sensing an acceleration indicative of a cardiac wall motion.

54. The method of claim 37, further comprising sensing a signal indicative of hemodynamic performance.

55. The method of claim 54, further comprising adjusting the one or more pacing parameters based on the signal indicative of hemodynamic performance.

56. The method of claim 54, wherein sensing the signal indicative of hemodynamic performance comprises sensing a signal indicative of minute ventilation.

57. The method of claim 54, wherein sensing the signal indicative of hemodynamic performance comprises sensing heart sounds, detecting first heart sounds (S1), and measuring one or more of an S1 amplitude and an S1 duration.

58. The method of claim 54, wherein sensing the signal indicative of hemodynamic performance comprises sensing heart sounds, detecting third heart sounds (S3), and measuring an S3 amplitude.

59. The method of claim 54, wherein sensing the signal indicative of hemodynamic performance comprises sensing a signal indicative of a left ventricular pressure and calculating an maximum positive derivative of the left ventricular pressure, LV+dp/dt.

60. The method of claim 54, wherein sensing the signal indicative of hemodynamic performance comprises sensing a signal indicative of stroke volume.

61. The method of claim 54, further comprising transmitting the at least one electrogram, the activity level, and the signal indicative of hemodynamic performance to an external system communicating with the implantable pacemaker via telemetry.

62. A cardiac pacing method, comprising:

sensing an activity level;

comparing the activity level to a predetermined threshold;

executing a cardiac resynchronization therapy (CRT) pacing algorithm if the activity level exceeds the predetermined threshold; and

executing a remodeling control therapy (RCT) pacing algorithm if the activity level does not exceed the predetermined threshold.

63. The method of claim 62, wherein sensing the activity level comprises sensing an acceleration.

64. The method of claim 62, wherein sensing the activity level comprises sensing a minute ventilation.

65. The method of claim 62, wherein sensing the activity level comprises sensing a heart rate.

66. The method of claim 62, wherein:

executing the CRT pacing algorithm comprises selecting a first set of pacing parameter values; and

executing the RCT pacing algorithm comprises selecting a second set of pacing parameter values.

67. The method of claim 66, wherein:

selecting the first set of pacing parameter values comprises selecting a first set of one or more pacing sites; and

selecting the second set of pacing parameter values comprises selecting a second set of one or more pacing sites.

68. The method of claim 66, wherein:

selecting the first set of pacing parameter values comprises setting at least one atrioventricular delay to a first time interval; and

selecting the second set of pacing parameter values comprises setting the at least one atrioventricular delay to a second time interval,

wherein the first time interval is longer than the second time interval.

69. The method of claim 68, wherein further comprising determining the second time interval for an optimal left ventricular stress distribution.

70. The method of claim 69, wherein further comprising determining the first time interval for a maximum positive derivative of the left ventricular pressure, LV+dp/dt.

71. The method of claim 69, wherein further comprising determining the first time interval for a maximum stroke volume.