System and method for adaptive drug delivery

• US 7,220,240 B2
• Filed: 09/27/2002
• Issued: 05/22/2007
• Est. Priority Date: 05/03/2000
• Status: Expired due to Term

• Current Assignee: Fresenius Vial SAS (Else Kröner-Fresenius-Stiftung)
• Original Assignee: Aspect Medical Systems, Inc. (Medtronic Plc)
• Inventors: De Smet, Tom, Versichelen, Linda, Struys, Michel
• Primary Examiner(s): Thanh; Loan H.
• Application Number:
  US10/256,817
• Publication Number:
  US 20030036744A1
• Time in Patent Office: 1,698 Days
• Field of Search: 604 65- 67
• US Class Current: 604/65
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence

Abstract

A system and method for controlling the administration of medication to a patient utilizes adaptive feedback to achieve and maintain a target effect in said patient. A sensor package having one or more sensors is used to sense an attribute of the patient and to provide a parameter indicating the attribute being sensed. A medication delivery controller accepts one or more parameters from the sensor package and uses these parameters to determine the effect of a medication on a patient and the concentration level of medication that will achieve a desired effect. The medication delivery controller controls the medication delivery unit to deliver the medication at a rate determined to achieve said target concentration level of said medication in said patient. If the patient'"'"'s response to a given medication changes as a result of external stimuli, the medication delivery controller can detect this change and determine a new concentration level of medication which will achieve the desired effect. The medication delivery controller can steer the medication delivery unit to administer an amount of medication to reach this new concentration level.

Claims

1. A medication delivery controller for controlling the administration of medication to a patient to achieve and maintain a target effect in said patient, the controller comprising:

a sensor interface configured to receive one or more patient parameters from a sensor package, said parameters quantifying the patient'"'"'s response to the level of medication,

a processor coupled to said sensor interface configured;

(a) to compute a first patient response profile, said first patient response profile indicating the patient'"'"'s individualized response to said medication;

(b) to determine from said first patient response profile a first concentration level of said medication to maintain said target effect in said patient;

(c) to determine whether the patient'"'"'s response to said first concentration level of said medication has changed and, when the patient'"'"'s response to said first concentration level has changed, to compute a second patient response profile reflecting the patient'"'"'s new individualized response to said medication and

(d) to determine from said second patient response profile a new concentration level of medication to maintain said target effect in said patient; and

a data output port coupled to said processor to forward instructions to a medication delivery unit to deliver said medication at said medication delivery rate determined by said processor, wherein said one or more parameters indicate at least one of the group of blood pressure, heart rate, temperature, and EEG parameters.

2. The medication delivery controller of claim 1 wherein said processor is further configured to allow said medication delivery controller to operate in an open-loop mode to determine said patient response profile.

3. The medication delivery controller of claim 1 wherein in said open loop mode, said medication delivery controller is configured to instruct said medication delivery unit to provide at least one level of concentration of medication to said patient and to measure the effect of said at least one level of concentration based on one or more parameters received from said one or more sensors.

4. The medication delivery controller of claim 1 wherein said concentration of medication in said patient is a blood concentration.

5. The medication delivery controller of claim 1, wherein said medication delivery unit comprises at least one of the group of an infusion pump and an inhalation delivery device.

6. The medication delivery controller of claim 1, wherein said medication is propofol.

7. A medication delivery controller for controlling the administration of medication to a patient to achieve and maintain a target effect in said patient, the controller comprising:

a sensor interface configured to receive one or more patient parameters from a sensor package, said parameters quantifying the patient'"'"'s response to the level of medication,

a processor coupled to said sensor interface configured;

to compute a first patient response profile, said first patient response profile indicating the patient'"'"'s individualized response to said medication;

to determine from said first patient response profile a first concentration level of said medication to maintain said taraet effect in said patient;

(c) to determine whether the patient'"'"'s response to said first concentration level of said medication has changed and, when the patient'"'"'s response to said first concentration level has changed, to compute a second patient response profile reflecting the patient'"'"'s new individualized response to said medication and

(d) to determine from said second patient response profile a new concentration level of medication to maintain said target effect in said patient; and

a data output port coupled to said processor to forward instructions to a medication delivery unit to deliver said medication at said medication delivery rate determined by said processor, wherein said concentration of medication in said patient is an effect-site concentration.

8. A method of using a medication delivery controller for controlling the administration of medication to a patient to achieve and maintain a target effect in said patient, the method comprising:

receiving one or more patient parameters from a sensor package, the parameters indicating one or more attributes sensed from the patient;

determining a target concentration level of said medication to achieve said target effect based on said one or more received parameters;

determining a medication delivery rate to achieve said target concentration level of said medication in said patient; and

instructing a medication delivery unit to deliver said medication at said medication delivery rate determined by said processor, wherein said one or more patient parameters indicate at least one of the group of blood pressure, heart rate, temperature, and EEG parameters.

9. The method of using a medication delivery controller of claim 8, wherein said method further comprises determining whether said target concentration level to achieve said target effect has changed, and controlling said medication delivery unit to deliver said medication at a second rate determined to achieve said changed target concentration level of said medication in said patient.

10. A method of using a medication delivery controller for controlling the administration of medication to a patient to achieve and maintain a target effect in said patient, the method comprising:

receiving one or more patient parameters from a sensor package, the parameters indicating one or more attributes sensed from the patient;

determining a target concentration level of said medication to achieve said target effect based on said one or more received parameters;

determining a medication delivery rate to achieve said target concentration level of said medication in said patient; and

instructing a medication delivery unit to deliver said medication at said medication delivery rate determined by said processor, wherein said method further comprises calculating a patient response profile and using said patient response profile to determine said target concentration level.

11. The method of using a medication delivery controller of claim 10, wherein said method further comprises instructing said medication delivery unit to provide at least one level of concentration of medication to said patient and to measure the effect of said at least one level of concentration based on one or more parameters received from said one or more sensors.

12. The method of using a medication delivery controller of claim 10, wherein said method further comprises:

delivering a first concentration level of medication to the patient;

determining an effect on the patient of said first concentration level of medication delivered to the patient;

delivering one or more increased concentration levels of medication to the patient;

determining an effect on the patient of said one or more increased concentration levels of medication delivered to the patient; and

calculating said patient response profile based on said effect of said medication on the patient.