Composition for maintaining organ and cell viability

  • US 7,220,538 B2
  • Filed: 05/07/2004
  • Issued: 05/22/2007
  • Est. Priority Date: 05/09/2003
  • Status: Active Grant
First Claim
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1. A two-phase composition comprising:

  • a first phase comprising a base nutritive medium; and

    a second phase comprising nanoparticles that comprise an outer lipophilic coating and an inner hydrophilic core, whereina) the first phase comprises physiologically compatible concentrations of water soluble or dispersible nutrients, and physiological salts;

    b) the nanoparticles of the second phase comprise lipids, fatty acids, sterols and free fatty acids; and

    c) the two-phase composition has an osmolality of at least about 300 mOsM/kg, andwherein the nanoparticles have a mean diameter ranging from about 100 nm to about 300 nm, and wherein the hydrophilic inner core of the nanoparticle contains a solution or suspension comprising a moiety capable of binding and releasing oxygen, and the first phase comprises a composition comprising Table 2A or Table 6, whereinTable 2A is;

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