Techniques to improve polyurethane membranes for implantable glucose sensors
First Claim
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1. A method for preparing an implantable homogeneous membrane, the method comprising the steps of:
- forming a composition comprising a dispersion of a hydrophobic-hydrophilic polymer within a matrix of a hydrophobic polymer;
maintaining the composition at a temperature sufficient to maintain solubility of the hydrophobic-hydrophilic polymer and the hydrophobic polymer;
applying the composition at the temperature to a substrate to form a film thereon; and
drying the film to form a membrane.
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Abstract
The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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US 8,112,138 B2
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Current Assignee
Abbott Diabetes Care Incorporated
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Original Assignee
Abbott Diabetes Care Incorporated
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US 8,112,240 B2
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Current Assignee
Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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US 8,121,857 B2
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Current Assignee
Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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US 8,135,548 B2
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Current Assignee
Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated, University of Virginia Patent Foundation
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US 8,149,103 B2
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Current Assignee
Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Current Assignee
Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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US 8,140,142 B2
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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US 8,140,312 B2
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Current Assignee
Abbott Diabetes Care Incorporated
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Original Assignee
Abbott Diabetes Care Incorporated
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Sanofi-Aventis Deutschland GmbH
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US 8,160,669 B2
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DexCom Incorporated
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Original Assignee
DexCom Incorporated
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US 8,160,670 B2
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Current Assignee
Abbott Diabetes Care Incorporated
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Original Assignee
Abbott Diabetes Care Incorporated
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US 8,160,900 B2
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Current Assignee
Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Current Assignee
Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Current Assignee
Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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US 8,185,181 B2
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Current Assignee
Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Current Assignee
Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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US 8,206,317 B2
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Current Assignee
Sanofi-Aventis Deutschland GmbH
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Sanofi-Aventis Deutschland GmbH
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US 8,206,319 B2
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Current Assignee
Sanofi-Aventis Deutschland GmbH
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Sanofi-Aventis Deutschland GmbH
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| Method and system for providing analyte monitoring | ||
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US 8,211,016 B2
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Current Assignee
Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Sanofi-Aventis Deutschland GmbH
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Current Assignee
Abbott Diabetes Care Incorporated
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Original Assignee
Abbott Diabetes Care Incorporated
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| Method of calibrating an analyte-measurement device, and associated methods, devices and systems | ||
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US 8,219,174 B2
Filed 06/29/2009
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Current Assignee
Abbott Diabetes Care Incorporated
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Original Assignee
Abbott Diabetes Care Incorporated
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US 8,216,138 B1
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Current Assignee
Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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US 8,216,154 B2
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Sanofi-Aventis Deutschland GmbH
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Sanofi-Aventis Deutschland GmbH
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| Method and system for providing analyte monitoring | ||
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US 8,216,137 B2
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Current Assignee
Abbott Diabetes Care Incorporated
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Original Assignee
Abbott Diabetes Care Incorporated
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US 8,219,173 B2
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Current Assignee
Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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US 8,221,334 B2
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Sanofi-Aventis Deutschland GmbH
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Sanofi-Aventis Deutschland GmbH
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| Analyte monitoring device and methods of use | ||
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US 8,224,413 B2
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Current Assignee
Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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US 8,224,415 B2
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Current Assignee
Abbott Diabetes Care Incorporated
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Original Assignee
Abbott Diabetes Care Incorporated
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US 8,223,021 B2
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Current Assignee
Therasense Incorporated
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Abbott Diabetes Care Incorporated
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| Analyte monitoring device and methods of use | ||
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US 8,226,558 B2
Filed 09/27/2010
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Current Assignee
Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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| Analyte monitoring device and methods of use | ||
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US 8,226,557 B2
Filed 12/28/2009
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Current Assignee
Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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| Analyte monitoring device and methods of use | ||
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US 8,226,555 B2
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Current Assignee
Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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US 8,226,891 B2
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Current Assignee
Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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US 8,229,535 B2
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Current Assignee
DexCom Incorporated
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DexCom Incorporated
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| Analyte monitoring device and methods of use | ||
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US 8,231,532 B2
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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US 8,236,242 B2
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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US 8,235,896 B2
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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US 8,235,915 B2
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Sanofi-Aventis Deutschland GmbH
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Sanofi-Aventis Deutschland GmbH
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Sanofi-Aventis Deutschland GmbH
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Sanofi-Aventis Deutschland GmbH
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US 8,252,229 B2
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Current Assignee
Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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US 8,255,032 B2
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Current Assignee
DexCom Incorporated
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DexCom Incorporated
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| Oxygen enhancing membrane systems for implantable devices | ||
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US 8,255,030 B2
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Current Assignee
DexCom Incorporated
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DexCom Incorporated
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US 8,255,031 B2
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Current Assignee
Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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| Oxygen enhancing membrane systems for implantable devices | ||
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US 8,255,033 B2
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Current Assignee
DexCom Incorporated
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DexCom Incorporated
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| Analyte monitoring device and methods of use | ||
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US 8,260,392 B2
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Current Assignee
Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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| Method and apparatus for providing data processing and control in a medical communication system | ||
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US 8,260,558 B2
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Current Assignee
Abbott Diabetes Care Incorporated
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Original Assignee
Abbott Diabetes Care Incorporated
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Sanofi-Aventis Deutschland GmbH
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Pelikan Technologies Inc.
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Abbott Diabetes Care Incorporated
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Original Assignee
Abbott Diabetes Care Incorporated
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US 8,267,870 B2
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Current Assignee
Sanofi-Aventis Deutschland GmbH
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Sanofi-Aventis Deutschland GmbH
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| Blood glucose tracking apparatus and methods | ||
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US 8,268,243 B2
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Current Assignee
Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Filed 11/24/2009
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Current Assignee
Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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| Analyte monitoring device and methods of use | ||
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US 8,273,022 B2
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Current Assignee
Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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| Analyte monitoring device and methods of use | ||
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US 8,275,439 B2
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Current Assignee
Abbott Diabetes Care Incorporated
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Original Assignee
Abbott Diabetes Care Incorporated
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US 8,277,713 B2
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Current Assignee
DexCom Incorporated
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DexCom Incorporated
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Sanofi-Aventis Deutschland GmbH
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Sanofi-Aventis Deutschland GmbH
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| Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge | ||
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US 8,282,577 B2
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Current Assignee
Sanofi-Aventis Deutschland GmbH
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Sanofi-Aventis Deutschland GmbH
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| Analyte monitoring device and methods of use | ||
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US 8,287,454 B2
Filed 09/27/2010
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Current Assignee
Abbott Diabetes Care Incorporated
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Original Assignee
Abbott Diabetes Care Incorporated
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US 8,296,918 B2
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Current Assignee
Sanofi-Aventis Deutschland GmbH
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Sanofi-Aventis Deutschland GmbH
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| Analyte monitoring device and methods of use | ||
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US 8,306,598 B2
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Current Assignee
Abbott Diabetes Care Incorporated
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Original Assignee
Abbott Diabetes Care Incorporated
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US 8,313,434 B2
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Current Assignee
DexCom Incorporated
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DexCom Incorporated
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| Tissue penetration device | ||
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US 8,333,710 B2
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Current Assignee
Sanofi-Aventis Deutschland GmbH
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Sanofi-Aventis Deutschland GmbH
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| Method and system for providing an integrated analyte sensor insertion device and data processing unit | ||
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US 8,333,714 B2
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Current Assignee
Abbott Diabetes Care Incorporated
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Original Assignee
Abbott Diabetes Care Incorporated
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US 8,337,421 B2
Filed 12/16/2008
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Current Assignee
Sanofi-Aventis Deutschland GmbH
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Sanofi-Aventis Deutschland GmbH
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| Tissue penetration device | ||
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US 8,337,419 B2
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Current Assignee
Sanofi-Aventis Deutschland GmbH
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Sanofi-Aventis Deutschland GmbH
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| Tissue penetration device | ||
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US 8,337,420 B2
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Current Assignee
Sanofi-Aventis Deutschland GmbH
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Sanofi-Aventis Deutschland GmbH
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| Tissue penetration device | ||
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Filed 12/23/2005
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Current Assignee
Sanofi-Aventis Deutschland GmbH
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Sanofi-Aventis Deutschland GmbH
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US 8,343,093 B2
Filed 05/28/2010
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Current Assignee
Abbott Diabetes Care Incorporated
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Original Assignee
Abbott Diabetes Care Incorporated
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US 8,343,092 B2
Filed 11/24/2009
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Current Assignee
Abbott Diabetes Care Incorporated
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Original Assignee
Abbott Diabetes Care Incorporated
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US 8,344,966 B2
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Current Assignee
Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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US 8,346,336 B2
Filed 03/18/2009
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Current Assignee
Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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| Analyte monitoring device and methods of use | ||
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US 8,346,337 B2
Filed 06/30/2009
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Current Assignee
Abbott Diabetes Care Incorporated
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Original Assignee
Abbott Diabetes Care Incorporated
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US 8,346,335 B2
Filed 01/30/2009
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Current Assignee
Abbott Diabetes Care Incorporated
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Original Assignee
Abbott Diabetes Care Incorporated
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US 8,353,881 B2
Filed 12/28/2005
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Current Assignee
Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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US 8,353,829 B2
Filed 12/21/2009
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Current Assignee
Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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US 8,357,091 B2
Filed 12/21/2009
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Current Assignee
Abbott Diabetes Care Incorporated
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Original Assignee
Abbott Diabetes Care Incorporated
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US 8,358,210 B2
Filed 11/24/2009
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Current Assignee
Therasense Incorporated
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Original Assignee
Abbott Diabetes Care Incorporated
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US 8,360,991 B2
Filed 12/23/2005
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Current Assignee
Sanofi-Aventis Deutschland GmbH
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Sanofi-Aventis Deutschland GmbH
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US 8,360,992 B2
Filed 11/25/2008
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Current Assignee
Sanofi-Aventis Deutschland GmbH
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Sanofi-Aventis Deutschland GmbH
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Current Assignee
Abbott Diabetes Care Incorporated
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Original Assignee
Abbott Diabetes Care Incorporated
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| Method and apparatus for penetrating tissue | ||
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Filed 12/03/2008
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Current Assignee
Sanofi-Aventis Deutschland GmbH
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Original Assignee
Sanofi-Aventis Deutschland GmbH
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| Analyte monitoring device and methods of use | ||
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US 8,366,614 B2
Filed 03/30/2009
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Current Assignee
Abbott Diabetes Care Incorporated
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Original Assignee
Abbott Diabetes Care Incorporated
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| Method and system for providing data communication in continuous glucose monitoring and management system | ||
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Filed 04/29/2010
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Current Assignee
Abbott Diabetes Care Incorporated
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Original Assignee
Abbott Diabetes Care Incorporated
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| Method and apparatus for body fluid sampling and analyte sensing | ||
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US 8,372,016 B2
Filed 09/30/2008
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Current Assignee
Sanofi-Aventis Deutschland GmbH
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Sanofi-Aventis Deutschland GmbH
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| Analyte monitoring device and methods of use | ||
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Filed 12/21/2009
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Current Assignee
Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Current Assignee
Abbott Diabetes Care Incorporated
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Original Assignee
Abbott Diabetes Care Incorporated
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Filed 11/23/2009
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Current Assignee
Abbott Diabetes Care Incorporated
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Original Assignee
Abbott Diabetes Care Incorporated
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Filed 08/31/2008
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Current Assignee
Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Current Assignee
Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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| Method and apparatus for penetrating tissue | ||
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US 8,382,682 B2
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Current Assignee
Sanofi-Aventis Deutschland GmbH
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Sanofi-Aventis Deutschland GmbH
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US 8,382,683 B2
Filed 03/07/2012
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Current Assignee
Sanofi-Aventis Deutschland GmbH
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Sanofi-Aventis Deutschland GmbH
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Filed 05/27/2008
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Current Assignee
Sanofi-Aventis Deutschland GmbH
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Original Assignee
Sanofi-Aventis Deutschland GmbH
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| RF tag on test strips, test strip vials and boxes | ||
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US 8,390,455 B2
Filed 11/24/2009
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Current Assignee
Therasense Incorporated
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Original Assignee
Abbott Diabetes Care Incorporated
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| Analyte monitoring device and methods of use | ||
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US 8,391,945 B2
Filed 03/17/2009
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Current Assignee
Abbott Diabetes Care Incorporated
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Original Assignee
Abbott Diabetes Care Incorporated
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| Method and apparatus for penetrating tissue | ||
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Current Assignee
Sanofi-Aventis Deutschland GmbH
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Original Assignee
Sanofi-Aventis Deutschland GmbH
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Sanofi-Aventis Deutschland GmbH
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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US 10,143,410 B2
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DexCom Incorporated
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DexCom Incorporated
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DexCom Incorporated
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DexCom Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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DexCom Incorporated
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GlySens Incorporated
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GlySens Incorporated
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DexCom Incorporated
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DexCom Incorporated
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DexCom Incorporated
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DexCom Incorporated
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DexCom Incorporated
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DexCom Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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DexCom Incorporated
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DexCom Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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GlySens Incorporated
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GlySens Incorporated
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GlySens Incorporated
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GlySens Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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GlySens Incorporated
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GlySens Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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DexCom Incorporated
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DexCom Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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DexCom Incorporated
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DexCom Incorporated
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DexCom Incorporated
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DexCom Incorporated
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DexCom Incorporated
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DexCom Incorporated
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DexCom Incorporated
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DexCom Incorporated
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DexCom Incorporated
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DexCom Incorporated
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DexCom Incorporated
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DexCom Incorporated
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GlySens Incorporated
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GlySens Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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DexCom Incorporated
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DexCom Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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DexCom Incorporated
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DexCom Incorporated
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DexCom Incorporated
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DexCom Incorporated
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DexCom Incorporated
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DexCom Incorporated
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DexCom Incorporated
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DexCom Incorporated
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DexCom Incorporated
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DexCom Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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Abbott Diabetes Care Incorporated
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DexCom Incorporated
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DexCom Incorporated
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Abbott Diabetes Care Incorporated
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