Air-in-line and pressure detection

• US 7,232,430 B2
• Filed: 07/06/2001
• Issued: 06/19/2007
• Est. Priority Date: 07/07/2000
• Status: Active Grant

• Current Assignee: FluidSense Corporation, Mack Ventures, Inc.
• Original Assignee: Mack Ventures, Inc.
• Inventors: Carlisle, Jeffrey A., Patel, Keena B.
• Primary Examiner(s): MENDEZ, MANUEL A
• Application Number:
  US09/899,300
• Publication Number:
  US 20020004645A1
• Time in Patent Office: 2,174 Days
• Field of Search: 604/65, 604/131, 604/66, 604/154, 604/67, 604/156, 604/30, 604/134, 604/31, 604/135, 604/32, 604/122, 604/48, 604/500, 128/DIG.12, 128/13
• US Class Current: 604/500
• CPC Class Codes: A61M 2205/12 with interchangeable cassettes forming partially or totally the fluid circuit
• CPC Class Codes: A61M 2205/128 with incorporated valves
• CPC Class Codes: A61M 2205/3355 Controlling downstream pump pressure
• CPC Class Codes: A61M 2205/3379 Masses, volumes, levels of fluids in reservoirs, flow rates
• CPC Class Codes: A61M 5/14224 Diaphragm type
• CPC Class Codes: A61M 5/16831 Monitoring, detecting, signalling or eliminating infusion flow anomalies low-level float-valves causing cut-off A61M5/40; indicating or recording presence, absence or direction of flow in general G01P13/0066

Abstract

Methods and apparatus for air content and pressure measurement of sample fluid, especially sample fluid in association with an infusion pump. Volume change in a chamber as the chamber transitions between negative and positive pressure relates to the air content in the chamber. In particular, in an infusion pump, the volume change of infusion fluid as it transitions between being under negative pressure and positive pressure within a cassette central chamber, e.g., pumping chamber, relates to the air content in the infusion fluid. The outlet pressure of the cassette central chamber, e.g., blood pressure, can be monitored based on the cassette central chamber pressure.

Claims

1. A method of determining pressure of a sample fluid comprising:

connecting the sample fluid to a chamber, wherein the chamber has an inlet valve, an outlet valve, and an assembly connected to a pressure source which pumps a chamber fluid out of the chamber, and wherein the sample fluid is connected to the chamber fluid through the outlet valve; and

determining chamber pressure when the pressure of the sample fluid equals the chamber pressure.

2. The method of claim 1, wherein the sample fluid is a body fluid of a mammal.

3. The method of claim 2, wherein the body fluid is blood.

4. The method of claim 2, wherein the body fluid is blood in a vessel selected from the group consisting of artery, vein, and capillary.

5. The method of claim 2, wherein the mammal is a human.

6. The method of claim 1, wherein the chamber is part of an infusion pump.

7. The method of claim 6, wherein the chamber fluid is an infusion fluid.

8. The method of claim 1, wherein the inlet valve of the chamber is closed when the pressure source pushes the chamber fluid out of the chamber.

9. The method of claim 1, wherein the assembly comprises a cassette piston.

10. The method of claim 9, wherein the determination of the chamber pressure includes determining position of the piston.

11. The method of claim 1, wherein the pressure source comprises a motor which generates a negative pressure in the chamber and pumps the chamber fluid into the chamber, and a spring which generates a positive pressure and pumps the chamber fluid out of the chamber.

12. The method of claim 11, wherein the determination of the position of the piston includes using an optical position sensor.

13. The method of claim 1 further comprising monitoring the pressure of the sample fluid including determining the pressure of the sample fluid at more than one time point over a period of time.

14. The method of claim 1 further comprising comparing the pressure of the sample fluid to a predetermined value.

15. An apparatus for monitoring pressure of a sample fluid comprising:

a central chamber with an inlet valve and an outlet valve, wherein a sample fluid is connected to a chamber fluid in the central chamber through the outlet valve.

an assembly moving in and out of the central chamber;

a pressure source connected to the assembly, and wherein the pressure source comprises a motor which generates a negative pressure in the central chamber and pumps fluid into the central chamber via the assembly, and a spring which generates a positive pressure in the central chamber and pumps fluid out of the central chamber via the assembly;

a position sensor connected to the assembly, wherein the position sensor determines a position change of the assembly; and

a processor connected to the position sensor, wherein the processor receives the position change of the assembly and calculates pressure of the central chamber when the pressure of the sample fluid equals the pressure of the central chamber.

16. The apparatus of claim 15, wherein the processor further compares the pressure of the sample fluid to a predetermined value.

17. The apparatus of claim 16 further comprising an alarming device connected to the processor, wherein the processor activates the alarming device when the pressure of the sample fluid equals or is beyond the predetermined value.

18. The apparatus of claim 16, wherein the processor prevents the fluid from leaving the central chamber when the pressure of the sample fluid equals or is beyond the predetermined value.

19. The apparatus of claim 18, wherein the processor closes the outlet valve and turns off the motor when the pressure of the sample fluid equals or is beyond the predetermined value.

20. The apparatus of claim 15 wherein the sample fluid is a body fluid of a mammal.

21. The apparatus of claim 20 wherein the body fluid is blood.

22. The apparatus of claim 20 wherein the body fluid is blood in a vessel selected from the group consisting of artery, vein, and capillary.

23. The apparatus of claim 15 wherein the chamber is part of an infusion pump.

24. The apparatus of claim 23 wherein the chamber fluid is an infusion fluid.

25. A method of determining pressure of a sample fluid comprising:

connecting the sample fluid to a chamber, wherein the chamber has an inlet valve, an outlet valve, and an assembly connected to a pressure source which assembly is operable to pump a chamber fluid out of the chamber, and wherein the sample fluid is connected to the chamber fluid through the outlet valve;

operating the assembly to pump chamber fluid out of the chamber through the outlet valve until the chamber pressure equals the pressure of the sample fluid; and

determining chamber pressure when the pressure of the sample fluid equals the chamber pressure.

26. The method of claim 25, wherein the sample fluid is a body fluid of a mammal.

27. The method of claim 26, wherein the body fluid is blood.

28. The method of claim 26, wherein the body fluid is blood in a vessel selected from the group consisting of artery, vein, and capillary.

29. The method of claim 26, wherein the mammal is a human.

30. The method of claim 25, wherein the chamber is part of an infusion pump.

31. The method of claim 30, wherein the chamber fluid is an infusion fluid.

32. The method of claim 25, wherein the inlet valve of the chamber is closed when the assembly is operated to pump chamber fluid out of the chamber.

33. The method of claim 25, wherein the assembly comprises a cassette piston.

34. The method of claim 33, wherein the determination of the chamber pressure includes determining position of the piston.

35. The method of claim 25, wherein the pressure source comprises a motor which generates a negative pressure in the chamber and pumps the chamber fluid into the chamber, and a spring which generates a positive pressure and pumps the chamber fluid out of the chamber.

36. The method of claim 35, wherein the determination of the position of the piston includes using an optical position sensor.

37. The method of claim 25 further comprising monitoring the pressure of the sample fluid including determining the pressure of the sample fluid at more than one time point over a period of time.

38. The method of claim 25 further comprising comparing the pressure of the sample fluid to a predetermined value.