Biosensor, measuring instrument for biosensor, and method of quantifying substrate

• US 7,232,510 B2
• Filed: 11/30/2001
• Issued: 06/19/2007
• Est. Priority Date: 11/30/2000
• Status: Expired due to Term

• Current Assignee: PHC Holdings Corporation
• Original Assignee: Matsushita Electric Industrial Company Limited (Panasonic Holdings Corporation)
• Inventors: Tokunaga, Hiroyuki, Tokuno, Yoshinobu, Miyazaki, Shoji, Matsumoto, Kazuhiro, Sawada, Yasuhiko
• Primary Examiner(s): Olsen; Kaj K.
• Application Number:
  US10/182,236
• Publication Number:
  US 20030159945A1
• Time in Patent Office: 2,027 Days
• Field of Search: 204/403.01, 204/403.02, 204/403.14, 204/406, 204/407
• US Class Current: 204/403.01
• CPC Class Codes: A61B 2562/0295 Strip shaped analyte sensors for apparatus classified in A61B5/145 or A61B5/157 disposable multilayered or laminated electrodes G01N27/307; details of handling chemical test elements G01N33/4875
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: C12Q 1/001 Enzyme electrodes
• CPC Class Codes: C12Q 1/005 involving specific analytes or enzymes including groups of enzymes, e.g. oxydases; C12Q1/004 takes precedence
• CPC Class Codes: C12Q 1/006 for glucose
• CPC Class Codes: G01N 27/26 by investigating electrochemical variables; by using electrolysis or electrophoresis
• CPC Class Codes: G01N 27/327 Biochemical electrodes , e.g. electrical or mechanical details for in vitro measurements
• CPC Class Codes: G01N 27/3272 Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels optical biosensors G01N33/52
• CPC Class Codes: G01N 27/3274 Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration coding of calibration information G01N33/48771
• CPC Class Codes: G01N 33/48771 Coding of information, e.g. calibration data, lot number
• CPC Class Codes: G01N 33/5438 Electrodes

Abstract

A biosensor, a measuring instrument for biosensor, and a method of quantifying a substrate contained in specimen liquid to reduce a measurement error by the biosensor; a biosensor, comprising at least a pair of electrodes formed on an insulation substrate; a measuring instrument, comprising a supporting part for detachably supporting the biosensor, a plurality of connection terminals electrically connected to the electrodes, and a drive power supply for applying a voltage to the electrodes through the connection terminals; wherein the biosensor is inserted into the measuring instrument, either one of the electrodes of the biosensor is connected to first and second connection terminals fined to the measuring instrument only when the biosensor is inserted into the support part of the measuring instrument in a specified direction and has an electrode structure to allow the first connection terminal to conduct with the second connection terminal when a voltage is applied by the drive power supply.

Claims

1. A biosensor system comprising:

a biosensor for measuring a quantity of a substrate included in a sample liquid, said biosensor comprising;

an insulating board having a front side and a back side, and

a pair of electrodes on said front side of said insulating board, said electrodes being arranged to measure said liquid sample; and

a measuring device comprising;

a supporting section for detachably supporting said biosensor in a plurality of directions including a predetermined direction and an upside-down direction opposite to the predetermined direction,

a plurality of connecting terminals operable to be coupled to the electrodes of said biosensor, respectively, said plurality of connecting terminals including first and second connecting terminals, wherein said first and second connecting terminals are connected to one of the electrodes of the biosensor only when the biosensor is inserted into said supporting section in the predetermined direction out of the plurality of directions,

a driving power supply for applying a voltage to the electrodes of said biosensor via said connecting terminals, wherein said driving power supply applies a voltage to said first and second connecting terminals for detecting conductivity between said first and second connecting terminals,

an output section for indicating that the biosensor is not inserted in the predetermined direction, wherein it is determined that the biosensor is not inserted in the predetermined direction when conductivity is not detected between said first and second connecting terminals, and

a conductivity detector to detect conductivity between connecting terminals coupled to one of the electrodes of the biosensor to determine whether the biosensor inserted into the measuring device is compatible with the measuring device and with measuring a blood sugar level.

2. The biosensor system of claim 1,

wherein said biosensor further comprises a conductive layer formed on at least a part of said front side of said insulating board, and

wherein the pair of electrodes comprises a counter electrode and a measuring electrode which are formed by dividing said conductive layer by a slit.

3. The biosensor system of claim 1, wherein said measuring device further comprises a display for providing a user with an alarm when said biosensor is inserted into a direction out of the plurality of directions other than the predetermined direction.

4. The biosensor system of claim 1, wherein the measuring device further comprises a voltage detector to detect a voltage between connecting terminals coupled to electrodes of the biosensor to determine whether a used biosensor is inserted into the measuring device.

5. The biosensor system of claim 1, wherein the measuring device comprises a voltage detector to detect a voltage between connecting terminals coupled to electrodes of the biosensor to determine whether the liquid sample has been applied to the biosensor as a drip error before the measuring device is ready for measurement.

6. The biosensor system of claim 1, wherein the biosensor is not compatible with measuring lactic acid or cholesterol.