IL-23p40 specific antibody
First Claim
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1. An isolated anti-interleukin (IL)-23p40 antibody, wherein said antibody specifically binds to a region comprising amino acids 138-145 of SEQ ID NO:
- 1, wherein said antibody binds the p40 subunit of the IL-23 protein and wherein said antibody does not bind the p40 subunit of the IL-12 protein.
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Abstract
Novel anti-IL-23p40 specific human Ig derived proteins, including, without limitation, antibodies, fusion proteins, and mimetibodies, isolated nucleic acids that encode the anti-IL-23p40 Ig derived proteins, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, are useful for therapeutic compositions, methods and devices. Preferably, the anti-IL-23p40 specific human Ig derived proteins do not bind the p40 subunit of IL-12 and, thus, do not neutralize IL-12-related activity.
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9 Claims
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1. An isolated anti-interleukin (IL)-23p40 antibody, wherein said antibody specifically binds to a region comprising amino acids 138-145 of SEQ ID NO:
- 1, wherein said antibody binds the p40 subunit of the IL-23 protein and wherein said antibody does not bind the p40 subunit of the IL-12 protein.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
Specification