Tissue implantable sensors for measurement of blood solutes

  • US 7,248,912 B2
  • Filed: 10/31/2003
  • Issued: 07/24/2007
  • Est. Priority Date: 10/31/2002
  • Status: Active Grant
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First Claim
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1. A device for estimating the concentration of an analyte in a biological environment, said device comprising:

  • (a) a housing;

    (b) at least two primary detectors disposed on the housing, wherein each primary detector is adapted to produce a signal responsive to the concentration of the analyte in the immediate biological microenvironment;

    (c) signal processing means in communication with each individual primary detector for receiving a signal therefrom and estimating the concentration of the analyte in the biological environment from the signals said signal processing means employing one or more predetermined algorithms, said signal processing means comprising;

    (i) means for adjusting the signals from each primary detector by applying signal adjustment coefficients thereto, wherein the coefficients compensate for detector failure, detector drift or variations between the biological microenvironments occupied by each detector;

    (ii) means for estimating the analyte concentration in the biological microenvironment of individual primary detectors; and

    (iii) means for estimating the concentration of the analyte by mathematical calculation of a primary composite signal indicative of said analyte concentration;

    (d) at least one secondary detector disposed on the housing, wherein each secondary detector is adapted to produce a signal responsive to one or more confounding phenomena in the biological microenvironment occupied by at least one primary detector;

    (e) signal processing means in communication with each individual secondary detector for receiving a signal responsive to the presence of a confounding phenomenon in the biological microenvironment occupied by at least one primary detector, and a signal responsive to the magnitude of a confounding phenomenon in the biological microenvironment occupied by the secondary detector; and

    ,(f) means for producing at least one secondary composite signal by adjusting detector signals from each secondary detector by applying signal adjustment coefficients thereto, wherein the coefficients have been selected to compensate for detector failure, detector drift, variations between biological microenvironments occupied by each secondary detector, and similarities between biological microenvironments occupied by secondary detectors and primary detectors with which they maybe associated.

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