Dual-use sensor for rate responsive pacing and heart sound monitoring

• US 7,248,923 B2
• Filed: 11/06/2003
• Issued: 07/24/2007
• Est. Priority Date: 11/06/2003
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Siejko, Krzysztof Z., Maile, Keith R.
• Primary Examiner(s): Layno; Carl
• Assistant Examiner(s): Johnson; Shevon
• Application Number:
  US10/703,175
• Publication Number:
  US 20050102001A1
• Time in Patent Office: 1,356 Days
• Field of Search: 607 1- 20, 600513-514, 600527-528
• US Class Current: 607/17
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters

Abstract

An implantable medical device includes a dual-use sensor such as a single accelerometer that senses an acceleration signal. A sensor processing circuit processes the acceleration signal to produce an activity level signal and a heart sound signal. The implantable medical device provides for rate responsive pacing in which at least one pacing parameter, such as the pacing interval, is dynamically adjusted based on the physical activity level. The implantable medical device also uses the heart sounds for pacing control purposes or transmits a heart sound signal to an external system for pacing control and/or diagnostic purposes.

Claims

1. A cardiac rhythm management system comprising:

a sensing circuit to sense at least one electrogram;

a pacing circuit to deliver pacing pulses;

a dual-use sensor to sense a signal indicative of activities and heart sounds;

a sensor processing circuit programmed to produce an activity level signal and a heart sound signal from the sensed signal, the sensor processing circuit including an input to receive the sensed signal indicative of activities and heart sounds, a first output representative of the activity level signal, and a second output representative of the heart sound signal; and

a controller coupled to the sensing circuit and the pacing circuit, the controller including;

a rate responsive pacing algorithm execution module to receive the activity level signal and dynamically adjust at least a pacing interval based on at least the activity level signal; and

a sensor processing circuit programming module coupled to the sensor processing circuit, the sensor processing circuit programming module programmed to program gains and cutoff frequencies for producing the activity level signal and the heart sound signal.

2. The system of claim 1, further comprising a memory circuit to synchronously store one or more of the at least one electrogram, the signal indicative of activities and heart sounds, the activity level signal, and the heart sound signal.

3. The system of claim 2, wherein the controller further comprises an event detector to detect cardiac events from the at least one electrogram and a marker generator to generate event markers each representing one of the detected cardiac events, and wherein the memory circuit further stores the event markers.

4. The system of claim 1, wherein the controller further comprises:

an analog-to-digital converter to digitize one or more of the at least one electrogram, the signal indicative of activities and heart sounds, the activity level signal, and the heart sound signal, the analog-to-digital converter having a programmable sampling rate; and

a digitization control module, coupled to the analog-to-digital converter, to control the sampling rate.

5. The system of claim 1, wherein the dual-use sensor is a single integrated circuit accelerometer.

6. The system of claim 1, further comprising a heart sound detector to receive the heart sound signal and detect at least one type of heart sound from the heart sound signal.

7. The system of claim 6, further comprising an implantable pacemaker including an implantable housing encapsulating the sensing circuit, the pacing circuit, the integrated circuit accelerometer, the sensor processing circuit, the pacing controller, and the heart sound detector.

8. The system of claim 1, wherein the sensor processing circuit comprises a band-pass filter having programmable cutoff frequencies.

9. The system of claim 8, wherein the band-pass filter has at least two sets of the programmable cutoff frequencies including a first set of cutoff frequencies suitable for producing the activity level signal and a second set of cutoff frequencies suitable for producing the heart sound signal.

10. The system of claim 9, wherein the sensor processing circuit programming module is adapted to program the programmable cutoff frequencies of the band-pass filter.

11. The system of claim 9, wherein the first set of cutoff frequencies comprises a first low cutoff frequency in a range of 0.5 Hz to 2 Hz and a first high cutoff frequency in a range of 5 Hz to 15 Hz.

12. The system of claim 9, wherein the second set of cutoff frequencies comprises a second low cutoff frequency in a range of 5 Hz to 10 Hz and a second high cutoff frequency in a range of 50 Hz to 200 Hz.

13. The system of claim 9, wherein the sensor processing circuit further comprises an amplifier coupled to the band-pass filter, the amplifier having a programmable gain.

14. The system of claim 13, wherein the amplifier has at least two gains selectable by the pacing controller, the at least two gains including a first gain suitable for producing the activity level signal and a second gain suitable for producing the heart sound signal.

15. The system of claim 14, wherein the first gain is in the range of 100 to 500.

16. The system of claim 14, wherein the second gain is in the range of 500 to 2000.

17. The system of claim 1, wherein the sensor processing circuit comprises a first band-pass filter and a second band-pass filter connected for concurrent processing of the signal indicative of activities and heart sounds, the first band-pass filter having a first set of cutoff frequencies suitable for producing the activity level signal, the second band-pass filter having a second set of cutoff frequencies suitable for producing the heart sound signal.

18. The system of claim 17, wherein the first set of cutoff frequencies comprises a first low cutoff frequency in a range of 0.5 Hz to 2 Hz and a first high cutoff frequency in a range of 5 Hz to 15 Hz.

19. The system of claim 17, wherein the second set of cutoff frequencies comprises a second low cutoff frequency in a range of 5 Hz to 10 Hz and a second high cutoff frequency in a range of 50 Hz to 200 Hz.

20. The system of claim 17, wherein the sensor processing circuit further comprises a first amplifier coupled to the first band-pass filter and a second amplifier coupled to the second band-pass filter, the first amplifier having a first gain suitable for producing the activity level signal, the second amplifier having a second gain suitable for producing the heart sound signal.

21. The system of claim 20, wherein the first gain is in the range of 100 to 500.

22. The system of claim 20, wherein the second gain is in the range of 500 to 2000.

23. A cardiac rhythm management system comprising:

an accelerometer to sense an acceleration signal indicative of physical activities and heart sounds; and

a processing circuit having an input to receive the acceleration signal, the processing circuit including;

a first amplifier having a programmable gain; and

a first band-pass filter having one or more cutoff frequencies programmable for producing an activity level signal during first time periods and producing a heart sound signal during second time periods; and

a controller coupled to the processing circuit, the controller including a processing circuit programming module programmed to program the gain and the one or more cutoff frequencies.

24. The system of claim 23, wherein the first amplifier having the programmable gain comprises an amplifier having programmable first and second gains, the first gain suitable for producing the physical activity level signal during the first time periods, the second gain suitable for producing the heart sound signal during the second time periods.

25. The system of claim 24, wherein the first gain is in the range of 100 to 500.

26. The system of claim 24, wherein the second gain is in the range of 500 to 2000.

27. The system of claim 23, wherein the first band-pass filter comprises a band-pass filter having programmable first and second sets of cutoff frequencies, the first set of cutoff frequencies suitable for producing the physical activity level signal, the second set of cutoff frequencies suitable for producing the heart sound signal.

28. The system of claim 27, wherein the first set of cutoff frequencies comprises a first low cutoff frequency in a range of 0.5 Hz to 2 Hz and a first high cutoff frequency in a range of 5 Hz to 15 Hz.

29. The system of claim 27, wherein the second set of cutoff frequencies comprises a second low cutoff frequency in a range of 5 Hz to 10 Hz and a second high cutoff frequency in a range of 50 Hz to 200 Hz.

30. The system of claim 23, further comprising a preconditioning circuit coupled between the accelerometer and the input of the processing circuit to precondition the acceleration signal.

31. The system of claim 30, wherein the preconditioning circuit comprises a preconditioning amplifier having a preconditioning gain in a range of 100 to 500.

32. The system of claim 31, wherein the preconditioning circuit further comprises a preconditioning band-pass filter having a preconditioning low cutoff frequency in a range of 0.5 Hz to 2 Hz and a preconditioning high cutoff frequency in a range of 50 Hz to 200 Hz.

33. The system of claim 32, wherein the preconditioning circuit further comprises an analog-to-digital converter to digitize the amplified and filtered acceleration signal, and wherein the processing circuit is a digital processing circuit.

34. The system of claim 33, wherein the analog-to-digital converter has a programmable sampling rate, and the controller further comprises digitization control module to control the sampling rate.

35. A cardiac rhythm management system comprising:

an accelerometer to sense an acceleration signal;

a first processing circuit including;

a first input to receive the acceleration signal;

a first output indicative of a physical activity level; and

a first gain-and-filter circuit, coupled between the first input and the first output, to provide for a first gain and a first set of cutoff frequencies; and

a second processing circuit including;

a second input to receive the acceleration signal;

a second output indicative of heart sounds; and

a second gain-and-filter circuit, coupled between the second input and the second output, to provide for a second gain and a second set of cutoff frequencies.

36. The system of claim 35, wherein the first gain-and-filter circuit comprises:

a first amplifier having the first gain; and

a first band-pass filter having the first set of cutoff frequencies.

37. The system of claim 36, wherein the first gain is in a range of 100 to 500.

38. The system of claim 36, wherein the first band-pass filter has a first low cutoff frequency in a range of 0.5 Hz to 2 Hz and a first high cutoff frequency in a range of 5 Hz to 15 Hz.

39. The system of claim 36, wherein the second gain-and-filter circuit comprises:

a second amplifier having the second gain; and

a second band-pass filter having the second set of cutoff frequencies.

40. The system of claim 39, wherein the second gain is in a range of 500 to 2000.

41. The system of claim 39, wherein the second band-pass filter has a second low cutoff frequency in a range of 5 Hz to 10 Hz and a second high cutoff frequency in a range of 50 Hz to 200 Hz.

42. The system of claim 39, further comprising a controller coupled to the first and second processing circuits, the controller including a sensor processing circuit programming module to program the first and second gains and the first and second sets of cutoff frequencies.

43. The system of claim 35, further comprising a preconditioning circuit including a third input connected to the accelerometer and a third output connected to the first and second inputs.

44. The system of claim 43, wherein the preconditioning circuit comprises a third amplifier having a third gain in a range of 100 to 500.

45. The system of claim 44, wherein the preconditioning circuit further comprises a third band-pass filter having a third low cutoff frequency in a range of 0.5 Hz to 2 Hz and a third high cutoff frequency in a range of 50 Hz to 200 Hz.

46. The system of claim 45, wherein the preconditioning circuit further comprises an analog-to-digital converter to digitize the amplified and filtered acceleration signal, and wherein the first and second processing circuits are digital processing circuits.

47. The system of claim 46, wherein the analog-to-digital converter has a programmable sampling rate, and further comprising a digitization control module to control the sampling rate.

48. A method comprising:

sensing a signal indicative of activities and heart sounds using a single implantable sensor;

programming gains and cutoff frequencies for producing an activity level signal and a heart sound signal using the sensed signal;

processing the sensed signal to produce the activity level signal and the heart sound signal;

executing a rate responsive pacing algorithm dynamically adjusting at least one pacing parameter based on the activity level signal; and

detecting at least one type of heart sounds from the heart sound signal.

49. The method of claim 48, wherein sensing the signal comprises sensing an acceleration signal.

50. The method of claim 49, further comprising sensing at least one electrogram, and wherein executing the rate responsive pacing algorithm comprises dynamically adjusting at least a pacing interval based on the at least one electrogram and the activity level signal.

51. The method of claim 50, further comprising:

detecting cardiac events from the at least one electrogram; and

generating event markers each representing one of the detected cardiac events.

52. The method of claim 51, further comprising synchronously storing one or more of the at least one electrogram, the event markers, the signal indicative of activities and heart sounds, the activity level signal, and the heart sound signal in an implantable medical device.

53. The method of claim 51, further comprising transmitting one or more of the at least one electrogram, the event markers, the signal indicative of activities and heart sounds, the activity level signal, and the heart sound signal from an implantable medical device to an external system in real time.

54. The method of claim 53, further comprising determining a therapy based on the one or more of the at least one electrogram, the event markers, the signal indicative of activities and heart sounds, the activity level signal, and the heart sound signal.

55. The method of claim 48, further comprising determining at least one further pacing parameter based on measurements from the detected at least one type of heart sounds.

56. The method of claim 48, further comprising:

measuring one or more parameters of the detected at least one type of heart sounds; and

trending the one or more parameters.

57. The method of claim 48, wherein processing the sensed signal comprises:

filtering the sensed signal using a first set of cutoff frequencies to produce the activity level signal; and

filtering the sensed signal using a second set of cutoff frequencies to produce the heart sound signal.

58. The method of claim 57, wherein processing the sensed signal comprises:

filtering the sensed signal using the first set of cutoff frequencies during first time periods; and

filtering the sensed signal using the second set of cutoff frequencies during second time periods.

59. The method of claim 57, wherein filtering the sensed signal comprises filtering the sensed signal using the first set of cutoff frequencies and the second set of cutoff frequencies concurrently.

60. The method of claim 57, wherein the first set of cutoff frequencies comprises a first low cutoff frequency in a range of 0.5 Hz to 2 Hz and a first high cutoff frequency in a range of 5 Hz to 15 Hz.

61. The method of claim 57, wherein the second set of cutoff frequencies comprises a second low cutoff frequency in a range of 5 Hz to 10 Hz and a second high cutoff frequency in a range of 50 Hz to 200 Hz.

62. The method of claim 57, wherein processing the signal further comprises:

providing the signal with a first gain to produce the activity level signal; and

providing

the signal with a second gain to produce the heart sound signal.

63. The method of claim 62, wherein the first gain is in the range of 100 to 500.

64. The method of claim 62, wherein the second gain is in the range of 500 to 2000.

65. A method comprising:

sensing an acceleration signal indicative of an activity level and heart sounds;

programming an amplifier with a first gain suitable for sensing the activity level for a first time period;

programming a band-pass filter with a first set of cutoff frequencies suitable for sensing an activity level for the first time period;

amplifying and filtering the sensed acceleration signal to produce an activity level signal;

programming the amplifier with a second gain suitable for sensing the heart sounds for a second time period;

programming the band-pass filter with a second set of cutoff frequencies suitable for sensing heart sounds for the second time period; and

amplifying and filtering the sensed acceleration signal to produce a heart sound signal.

66. The method of claim 65, wherein programming the band-pass filter with the first set of cutoff frequencies comprises programming the band-pass filter with a first low cutoff frequency in a range of 0.5 Hz to 2 Hz and a first high cutoff frequency in a range of 5 Hz to 15 Hz.

67. The method of claim 65, wherein programming the band-pass filter with the second set of cutoff frequencies comprises programming the band-pass filter with a second low cutoff frequency in a range of 5 Hz to 10 Hz and a second high cutoff frequency in a range of 50 Hz to 200 Hz.

68. The method of claim 65, wherein programming the amplifier with the first gain comprises programming the amplifier with a gain in the range of 100 to 500.

69. The method of claim 65, wherein programming the amplifier with the second gain comprises programming the amplifier with a gain in the range of 500 to 2000.

70. The method of claim 65, further comprising digitizing the acceleration signal before the amplifying and filtering the acceleration signal to produce the activity level signal and the amplifying and filtering the sensed acceleration signal to produce a heart sound signal.

71. A method comprising:

sensing an acceleration signal; and

producing an activity level signal and a heart sound signal concurrently from the acceleration signal, including;

amplifying the acceleration signal with a first gain suitable for producing the activity level signal;

filtering the acceleration signal with a first set of cutoff frequencies suitable for producing the activity level signal;

amplifying the acceleration signal with a second gain suitable for producing the heart sound signal; and

filtering the acceleration signal with a second set of cutoff frequencies suitable for producing the heart sound signal.

72. The method of claim 71, wherein amplifying the acceleration signal with the first gain comprises amplifying the acceleration signal with a gain in a range of 100 to 500.

73. The method of claim 72, wherein filtering the acceleration signal with the first set of cutoff frequencies comprises filtering the acceleration signal with a first low cutoff frequency in a range of 0.5 Hz to 2 Hz and a first high cutoff frequency in a range of 5 Hz to 15 Hz.

74. The method of claim 71, wherein amplifying the acceleration signal with the second gain comprises amplifying the acceleration signal with a gain in a range of 500 to 2000.

75. The method of claim 74, wherein filtering the acceleration signal with the second set of cutoff frequencies comprises filtering the acceleration signal with a second low cutoff frequency in a range of 5 Hz to 10 Hz and a second high cutoff frequency in a range of 50 Hz to 200 Hz.

76. The method of claim 71, further comprising pre-conditioning the acceleration signal, and wherein producing the activity level signal and the heart sound signal from the acceleration signal comprises producing the activity level signal and the heart sound signal from the pre-conditioned acceleration signal.

77. The method of claim 76, wherein pre-conditioning the acceleration signal comprises amplifying the acceleration signal with a gain in a range of 100 to 500.

78. The method of claim 77, wherein pre-conditioning the acceleration signal further comprises filtering the acceleration signal with a low cutoff frequency in a range of 0.5 Hz to 2 Hz and a high cutoff frequency in a range of 50 Hz to 200 Hz.

79. The method of claim 77, further comprising digitizing the acceleration signal before the producing the activity level signal and the heart sound signal concurrently from the acceleration signal.