Spinal cord stimulation as treatment for functional bowel disorders

• US 7,251,529 B2
• Filed: 05/29/2003
• Issued: 07/31/2007
• Est. Priority Date: 05/29/2002
• Status: Expired due to Fees

• Current Assignee: Oklahoma Foundation For Digestive Research
• Original Assignee: Oklahoma Foundation For Digestive Research
• Inventors: Greenwood-Van Meerveld, Beverley
• Primary Examiner(s): Layno; Carl
• Assistant Examiner(s): LEE, YUN HAENG NMN
• Application Number:
  US10/448,448
• Publication Number:
  US 20040039425A1
• Time in Patent Office: 1,524 Days
• Field of Search: 607 40- 41, 607/46, 607/117, 607/133
• US Class Current: 607/46
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/3752 Details of casing-lead connections

Abstract

The present invention relates to treatment of visceral pain of gastrointestinal origin, functional bowel disorders and irritable bowel syndrome comprising electrical stimulation of the spinal cord using one or more commercially available and implantable spinal cord stimulation leads for a time period sufficient to suppress or extinguish the pain or symptoms associated with visceral pain of gastrointestinal origin, functional bowel disorders or irritable bowel syndrome.

Claims

1. A method of treating a functional bowel disorder comprising electrically stimulating the spinal cord until a symptom associated with the functional bowel disorder is relieved and wherein said step of stimulating the spinal cord is sufficient to inhibit inflammation and suppress abdominal reflex contractions.

2. The method of claim 1 wherein the functional bowel disorder is irritable bowel syndrome.

3. The method of claim 2 further comprising suppressing pain associated with irritable bowel syndrome.

4. The method of claim 3 wherein the suppression of pain persists after completion of the step of electrically stimulating the spinal cord.

5. The method of claim 1 wherein the stimulating step is performed at a level greater than about 80% of motor threshold.

6. The method of claim 1 wherein said step of stimulating the spinal cord decreases myeloperoxidase activity.

7. The method of claim 1 wherein said step of stimulating the spinal cord produces changes in neuronal activity and neurotransmitter release occur.

8. The method of claim 1 further comprising:

implanting a lead comprised of two electrodes into the epidural space overlying the spinal cord;

connecting the lead to a lead extension connector;

connecting the lead extension connector to a power source capable of generating electrical power; and

energizing the power source for a period of time sufficient to suppress said symptom of gastrointestinal origin.

9. The method of claim 8 further comprising varying at least one characteristics of the electrical power generated by the power source.

10. A method of suppressing pain of gastrointestinal origin comprising:

implanting a lead comprised of two electrodes into the epidural space overlying the spinal cord;

connecting the lead to a lead extension connector;

connecting the lead extension connector to a power source capable of generating electrical power; and

energizing the power source for a period of time sufficient to suppress the pain of gastrointestinal origin and wherein said step of energizing the power source is sufficient to inhibit inflammation, suppress abdominal reflex contractions and decrease myeloperoxidase activity.

11. The method of claim 10 wherein the pain of gastrointestinal origin is associated with a functional bowel disorder.

12. The method of claim 11 wherein the functional bower disorder is irritable bowel syndrome.

13. The method of claim 10 further comprising varying at least one characteristic of the electrical power generated by the power source.

14. The method of claim 13 wherein one characteristic of the electrical power that is varied is amplitude.

15. The method of claim 13 wherein one characteristic of the electrical power that is varied is pulse width.

16. The method of claim 13 wherein one characteristic of the electrical power that is varied is rate.

17. The method of claim 10 wherein said step of energizing the power source provides an electrical signal sufficient to suppress abdominal cramps and further comprising the step of identifying at least one of the following electrical signal characteristics for a specific patient:

amplitude, pulse width, rate and duration of electrical power applied.

18. The method of claim 10 wherein the pain suppression persists when the power source is no longer energized.

19. The method of claim 18 wherein the energizing step is performed at a level greater than about 80% of motor threshold.

20. The method of claim 10 wherein changes in neuronal activity and neurotransmitter release occur.

21. A method of treating irritable bowel syndrome comprising:

providing a spinal cord stimulating device; and

stimulating a spinal cord to suppress pain associated with irritable bowel syndrome and to inhibit inflammation, suppress abdominal reflex contractions and decrease myeloperoxidase activity.

22. The method of claim 21 wherein suppression of pain persists after completion of use of the spinal cord stimulating device.

23. The method of claim 21 wherein said step of stimulating a spinal cord is carried out for a period of time sufficient to suppress abdominal cramps associated with irritable bowel syndrome.

24. The method of claim 21 further comprising varying an electrical power component of the spinal cord stimulation device.

25. The method of claim 24 wherein the electrical power component that is varied is amplitude.

26. The method of claim 24 wherein the electrical power component that is varied is pulse width.

27. The method of claim 24 wherein the electrical power component that is varied is rate.

28. The method of claim 21 wherein the stimulating step is performed at a level greater than about 80% of motor threshold.

29. The method of claim 21 wherein changes in neuronal activity and neurotransmitter release occur.