Method of producing biologically active human acidic fibroblast growth factor and its use in promoting angiogenesis

  • US 7,252,818 B2
  • Filed: 08/27/2003
  • Issued: 08/07/2007
  • Est. Priority Date: 07/24/1998
  • Status: Expired due to Term
First Claim
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1. A method for increasing cardiac efficiency of a heart having an ischemic myocardial region in a human subject, comprising the steps of:

  • (a) preparing a pharmaceutical composition comprising a recombinant fibroblast growth factor-1 (FGF-1);

    (b) injecting an amount of said pharmaceutical composition into the ischemic region of the myocardium, said amount being sufficient to induce local neoangiogenesis; and

    (c) evaluating at least one clinical index of cardiac function to confirm that cardiac efficiency has increased.

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