Chemical sensors from nanoparticle/dendrimer composite materials

• US 7,253,004 B2
• Filed: 07/18/2002
• Issued: 08/07/2007
• Est. Priority Date: 07/19/2001
• Status: Active Grant

• Current Assignee: Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften e.V. (Max-Planck-Gesellschaft zur Frderung der Wissenschaften e), Sony Deutschland GmbH (Sony Group Corp.)
• Original Assignee: Sony Deutschland GmbH (Sony Group Corp.)
• Inventors: Yasuda, Akio, Vossmeyer, Tobias, Mullen, Klaus, Bauer, Roland E.
• Primary Examiner(s): Siefke; Samuel P
• Application Number:
  US10/197,905
• Publication Number:
  US 20030109056A1
• Time in Patent Office: 1,846 Days
• Field of Search: 422/50, 422/55, 422/68.1, 422/82.05
• US Class Current: 436/169
• CPC Class Codes: B82Y 15/00 Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• CPC Class Codes: G01N 21/77 by observing the effect on a chemical indicator
• CPC Class Codes: G01N 27/126 comprising organic polymers
• CPC Class Codes: G01N 33/0001 by organoleptic means
• CPC Class Codes: Y10T 436/11 Automated chemical analysis

Abstract

The invention relates to a chemical sensor comprising a sensor film formed of a nanoparticle network in which the nanoparticles are interlinked by functionalized dendrimer molecules. The dendrimers support an efficient uptake of analyte molecules by the film material and therefore enable a high sensitivity of the sensor. In addition, the chemical nature of the dendrimers strongly determines the chemical selectivity of the sensor device. By cross-linking the components of the sensitive material the sensor displays a good mechanical stability.

Claims

1. A chemical sensor, comprising:

a substrate having a surface;

a sensor medium formed on the substrate; and

a detection means for detecting a change of a physical property of the sensor medium,

wherein the sensor medium comprises a network formed of non-linear polymer or oligomer molecules having linker units and of particles of at least one second component,

wherein the linker units are bound to the surface of the particles of the at least one second component thereby interlinking the particles,

wherein the particles of the at least one second component are nanoparticles,

wherein the nanoparticles consist of a metal, and

wherein the chemical sensor is exposed to an analyte and a change of a physical property of the sensor film is measured by detection, wherein the change of the physical property is a change of the electronic transport properties.

2. The chemical sensor according to claim 1, wherein the non-linear polymer or oligomer molecule is a dendrimer molecule.

3. The chemical sensor according to claim 2, wherein the dendrimer molecules comprise an interior formed of a core and a shell of branched repeating units, and an outer shell of linker units.

4. The chemical sensor according to claim 1, wherein the linker units are formed by polar groups.

5. The chemical sensor according to claim 1 wherein the linker unit comprises a sulphur-containing group.

6. The chemical sensor according to claim 4, wherein the linker unit is selected from a group consisting of disulfide group, thiol group, thiolate group, isocyanate group, thiocarbamate group, dithiocarbamate group, sulfonium group, and amino group.

7. The chemical sensor according to claim 3, wherein at least 40% of the carbon atoms of the core and the shell of branched repeating units are sp₂ or sp hybridized.

8. The chemical sensor according to claim 3, wherein the dendrimer core and/or the shell of branched repeating units comprise at least one structural unit, selected from the group consisting of adamantane, cyclodextrin, crown ether, porphyrin, and phthalocyanine.

9. The chemical sensor according to claim 3, wherein the core and/or the shell of branched repeating units comprise polar endo-receptor sites.

10. The chemical sensor according to claim 3, wherein the dendrimer molecule is a polyamidoamine (PAMAM) dendrimer.

11. The chemical sensor according to claim 2, wherein the dendrimer molecule is a poly(propylene imine) (PPI) dendrimer.

12. The chemical sensor according to claim 3, wherein the core and/or the shell of branched repeating units comprise electron-donating groups, which are complexed with metal cations.

13. The chemical sensor according to claim 3, wherein the interior of the dendrimer molecule has a hydrophobic structure.

14. The chemical sensor according to claim 13, wherein the hydrophobic structure is formed by a polyphenylene structure or comprises phenylene units.

15. The chemical sensor according to claim 2, wherein the dendrimer molecule is a metallodendrimer.

16. The chemical sensor according to claim 2, wherein the shell of linker units is connected to the shell of branched repeating units by a shell of spacer units.

17. Chemical sensor according to claim 16, wherein the spacer units have a flexible structure comprising alkylene chains which comprise at least three carbon atoms.

18. The chemical sensor according to claim 1, wherein the metal is selected from the group consisting of Au, Ag, Pt, Pd, Co, Cu, Ni, Cr, Mo, Zr, Nb, Fe, or any combination of those metals.

19. The chemical sensor according to claim 1, wherein the chemical sensor is formed as a chemical sensitive resistor, a chemical sensitive transistor, a chemical sensitive diode, or a chemical sensitive capacitor.

20. The chemical sensor according to claim 1, wherein the surface of the substrate is functionalized in order to provide linker groups on the surface of the substrate.

21. A chemical sensor, comprising:

a substrate having a surface;

a sensor medium formed on the substrate; and

a detection means for detecting a change of a physical property of the sensor medium,

wherein the sensor medium comprises a network formed of non-linear polymer or oligomer molecules having linker units and of particles of at least one second component,

wherein the linker units are bound to the surface of the particles of the at least one second component thereby interlinking the particles,

wherein the dendrimer molecules comprise an interior formed of a core and a shell of branched repeating units, and an outer shell of linker units, and

wherein the dendrimer core and/or the shell of branched repeating units comprise at least one structural unit, selected from the group consisting of adamantane, cyclodextrin, crown ether, porphyrin, and phthalocyanine.