Lubricious coating for medical devices

• US 7,264,859 B2
• Filed: 11/10/2003
• Issued: 09/04/2007
• Est. Priority Date: 12/19/2002
• Status: Active Grant

• Current Assignee: O&M Halyard, Inc. (Owens and Minor Incorporated)
• Original Assignee: Kimberly-Clark Worldwide Incorporated (Kimberly-Clark Corporation)
• Inventors: Perrault, James, Rouns, Cameron
• Primary Examiner(s): ZACHARIA, RAMSEY E
• Application Number:
  US10/705,751
• Publication Number:
  US 20040151930A1
• Time in Patent Office: 1,394 Days
• Field of Search: 428/36.91, 428/424.4, 428/447, 428/520, 428/522, 604/265
• US Class Current: 428/36.91
• CPC Class Codes: A61L 2400/10 Materials for lubricating medical devices
• CPC Class Codes: A61L 2420/02 Methods for coating medical devices
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/44 having a macromolecular matrix
• CPC Class Codes: A61L 27/52 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 29/041 obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/126 having a macromolecular matrix
• CPC Class Codes: A61L 29/14 Materials characterised by their function or physical properties , e.g. lubricating compositions
• CPC Class Codes: A61L 29/145 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/125 having a macromolecular matrix
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: C08L 33/00 Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
• CPC Class Codes: Y10T 428/1393 Multilayer [continuous layer]
• CPC Class Codes: Y10T 428/31576 Ester monomer type [polyvinylacetate, etc.]
• CPC Class Codes: Y10T 428/31663 As siloxane, silicone or silane
• CPC Class Codes: Y10T 428/31855 Of addition polymer from unsaturated monomers
• CPC Class Codes: Y10T 428/31928 Ester, halide or nitrile of addition polymer
• CPC Class Codes: Y10T 428/31935 Ester, halide or nitrile of addition polymer

Abstract

Medical devices having at least a portion thereof coated with a lubricious polymer are disclosed. The lubricious polymer can be, for instance, a hydrogel polymer, such as a quaternary amine acrylate polymer. To bond the lubricious polymer to the surface of the medical device, the medical device is first subjected to a solvent and a multi-functional monomer. The solvent causes the multi-functional monomer to become imbibed into the surface of the medical device. Thereafter, a polymer having lubricious properties is polymerized on the surface of the device. The multi-functional monomer reacts with the polymer coating securely affixing the polymer coating to the device.

Claims

1. A medical device comprising:

a surface configured to move in relation to an adjacent surface; and

a lubricious coating applied to the surface, the lubricious coating comprising a quaternary amine acrylate hydrogel polymer that has been cross-linked to a multi-functional monomer, the multi-functional monomer having been imbibed into the surface of the medical device, the multi-functional monomer comprising an acrylate or an ammonium compound.

2. A medical device as defined in claim 1, wherein the surface of the device is made from a thermoplastic or a thermoset.

3. A medical device as defined in claim 1, wherein the surface of the device is made from polyvinyl chloride.

4. A medical device as defined in claim 1, wherein the quaternary amine acrylate hydrogel polymer is formed from a monomer having the structure:

5. A medical device as defined in claim 1, wherein the medical device comprises tracheal suction device, a catheter, a guidewire, a stylet, an enteral feeding device, an introducer, or an endotracheal tube.

6. A medical device as defined in claim 1, wherein the surface of the device is made from a silicone or a urethane.

7. A medical device as defined in claim 1, wherein the quaternary amine acrylate hydrogel polymer comprises acryloyloxyalkyl-trialkyl-substituted ammonium salt, an acryloyloxyalkyl-aryl-substituted ammonium salt, an acrylamidoalkyl-trialkyl-substituted ammonium salt, or an acrylamidoalkyl-aryl-substituted ammonium salt.

8. A medical device as defined in claim 1, wherein the quaternary amine acrylate hydrogel polymer comprises acryloyloxyethyltrimethyl ammonium chloride, or acryloyloxyethyltrimethyl ammonium methyl sulfate.

9. A medical device as defined in claim 1 wherein the multi-functional monomer comprises an alkoxylated acrylate.

10. A medical device as defined in claim 1 wherein the multi-functional monomer comprises a triacrylate.

11. A medical device as defined in claim 1, wherein the multi-functional monomer comprises a tetraacrylate, a pentaacrylate, a hexaacrylate, or a diacrylate.

12. A medical device as defined in claim 1, wherein the multi-functional monomer comprises an ethoxylated trimethylolpropane triacrylate, a propoxylated glyceryl triacrylate, trimethylolpropane triacrylate, pentaerythritol triacrylate, a propoxylated glyceryl triacrylate, a propoxylated trimethylolpropane triacrylate, trimethylol propane trimethacrylate, tris (2-hydroxy ethyl) isocyanurate triacrylate, di-trimethylolpropane tetraacrylate, dipentaerythritol pentaacrylate, an ethoxylated pentaerythritol tetraacrylate, a dipentaerythritol pentaacrylate, a pentaacrylate ester, pentaerythritol tetraacrylate, or a caprolactone modified dipentaerythritol hexaacrylate.

13. A medical device as defined in claim 1, wherein the multi-functional monomer comprises N,N-Dimethylaminoethyl acrylate dimethylsulfate, N,N-Dimethylaminoethyl acrylate methylchloride, N,N-Dimethylaminoethyl methacrylate dimethylsulfate, N,N-Dimethylaminoethyl methacrylate methylchloride, Diallyldimethylammonium chloride, acryloxyethyldimethyl benzyl ammonium chloride, acryloxyethyltrimethyl ammonium chloride, methacryloxyethyldimethyl benzyl ammonium chloride, or methacryloxyethyltrimethyl ammonium chloride.

14. A medical device as defined in claim 1, wherein the multi-functional monomer comprises an ethoxylated trimethylolpropane triacrylate.