MRI/NMR-compatible, tidal volume control and measurement systems, methods, and devices for respiratory and hyperpolarized gas delivery
First Claim
1. A method of delivering hyperpolarized gas to a subject, comprising:
- providing a ventilator system with a mass flow controller, a tracheal tube and a gas delivery valve configured to deliver hyperpolarized gas and at least one non-polarized gas to a subject;
monitoring a first pressure in the ventilator system upstream of the gas delivery valve;
monitoring a second pressure in the ventilator system downstream of the gas delivery valve;
obtaining a reading of the mass flow controller when the first pressure is substantially constant; and
automatically determining the tidal inspiration volume of hyperpolarized gas delivered to the subject in situ using the obtained mass flow controller reading.
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Accused Products
Abstract
Ventilator systems include: (a) a mass flow controller; (b) a gas delivery valve in communication with the mass flow controller and configured to selectively dispense a plurality of different gases to a subject; (c) a first gas source in fluid communication with the gas delivery valve; (d) a second gas source in fluid communication with the gas delivery valve; (e) a first pressure sensor located upstream of the gas delivery valve; (f) a second pressure sensor located downstream of the gas delivery valve; and (g) a controller operatively associated with the first and second pressure sensors and the mass flow controller, the controller comprising computer program code that monitors the pressures measured by the first and second pressure sensors and automatically dynamically adjusts the flow rate of the mass flow controller.
120 Citations
27 Claims
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1. A method of delivering hyperpolarized gas to a subject, comprising:
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providing a ventilator system with a mass flow controller, a tracheal tube and a gas delivery valve configured to deliver hyperpolarized gas and at least one non-polarized gas to a subject; monitoring a first pressure in the ventilator system upstream of the gas delivery valve; monitoring a second pressure in the ventilator system downstream of the gas delivery valve; obtaining a reading of the mass flow controller when the first pressure is substantially constant; and automatically determining the tidal inspiration volume of hyperpolarized gas delivered to the subject in situ using the obtained mass flow controller reading. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A ventilator system having a ventilation flow path for ventilating a subject, comprising:
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a gas delivery valve configured to selectively dispense a plurality of different gases to a subject; a mass flow controller disposed upstream of the gas delivery valve; a first polarized gas source in fluid communication with the gas delivery valve; a second gas source in fluid communication with the gas delivery valve; a first pressure sensor located upstream of the gas delivery valve; a second pressure sensor located downstream of the gas delivery valve; and a manifold line having a fluidic tunable capacitance disposed upstream of the gas delivery valve, wherein the fluidic capacitance has a volume that is at least about ten times greater than the volume of the lungs of the subject. - View Dependent Claims (25, 26, 27)
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Specification